{"title":"Run-Length-Limited ISI-Mitigation (RLIM) Coding for Molecular Communication","authors":"Melih Şahin;Ozgur B. Akan","doi":"10.1109/TMBMC.2026.3659828","DOIUrl":null,"url":null,"abstract":"Inter-symbol interference (ISI) limits reliability in diffusion-based molecular communication (MC) channels. We propose RLIM, a family of run-length-limited (RLL) codes that form fixed-size codebooks by minimizing the total number of 1-bits, increasing the per-symbol molecule budget under standard power normalizations and thus improving reliability. We develop a provably optimal linear-time greedy decoder that is equivalent to Viterbi decoding under a deterministic last-wins tie-break and has lower computational complexity; empirically, it outperforms first-wins and random Viterbi variants on RLL baselines. Extensive binomial and particle-tracking simulations show that RLIM achieves lower bit error rate (BER) than classical RLL and other prominent coding schemes across a broad range of scenarios.","PeriodicalId":36530,"journal":{"name":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","volume":"12 ","pages":"376-387"},"PeriodicalIF":2.5000,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Transactions on Molecular, Biological, and Multi-Scale Communications","FirstCategoryId":"1085","ListUrlMain":"https://ieeexplore.ieee.org/document/11369871/","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 0
Abstract
Inter-symbol interference (ISI) limits reliability in diffusion-based molecular communication (MC) channels. We propose RLIM, a family of run-length-limited (RLL) codes that form fixed-size codebooks by minimizing the total number of 1-bits, increasing the per-symbol molecule budget under standard power normalizations and thus improving reliability. We develop a provably optimal linear-time greedy decoder that is equivalent to Viterbi decoding under a deterministic last-wins tie-break and has lower computational complexity; empirically, it outperforms first-wins and random Viterbi variants on RLL baselines. Extensive binomial and particle-tracking simulations show that RLIM achieves lower bit error rate (BER) than classical RLL and other prominent coding schemes across a broad range of scenarios.
期刊介绍:
As a result of recent advances in MEMS/NEMS and systems biology, as well as the emergence of synthetic bacteria and lab/process-on-a-chip techniques, it is now possible to design chemical “circuits”, custom organisms, micro/nanoscale swarms of devices, and a host of other new systems. This success opens up a new frontier for interdisciplinary communications techniques using chemistry, biology, and other principles that have not been considered in the communications literature. The IEEE Transactions on Molecular, Biological, and Multi-Scale Communications (T-MBMSC) is devoted to the principles, design, and analysis of communication systems that use physics beyond classical electromagnetism. This includes molecular, quantum, and other physical, chemical and biological techniques; as well as new communication techniques at small scales or across multiple scales (e.g., nano to micro to macro; note that strictly nanoscale systems, 1-100 nm, are outside the scope of this journal). Original research articles on one or more of the following topics are within scope: mathematical modeling, information/communication and network theoretic analysis, standardization and industrial applications, and analytical or experimental studies on communication processes or networks in biology. Contributions on related topics may also be considered for publication. Contributions from researchers outside the IEEE’s typical audience are encouraged.