Demyelinating Neurobrucellosis Presenting With Neuropsychiatric Manifestations.

Abstract

Neurobrucellosis with psychiatric manifestations is an uncommon manifestation of brucellosis. Herein, we report a 31-year-old male complaining of dizziness, nausea, malaise, imbalance, amnesia, psychosis, delusion, and impulsive and disorganized behavior. He was not responsive to antipsychotic treatment, and his brain MRI showed demyelinating hyperintensity foci in the periventricular and paraventricular areas and the subcortical areas of the right temporal and frontal lobes. His serum and cerebrospinal fluid serology were in favor of brucellosis, and he dramatically responded to anti-Brucella medications. Although demyelinating neurobrucellosis with psychiatric manifestations is rare, it should be suspected in unresponsive patients coming from brucellosis-endemic areas.