Effectiveness of noninvasive respiratory strategies for the management of postoperative hypoxaemia in dogs: a prospective, randomized clinical trial

IF 2.5 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia Pub Date : 2026-05-01 Epub Date: 2026-01-08 DOI:10.1016/j.vaa.2026.101187

Claudia Piemontese , Marzia Stabile , Caterina Vicenti , Annalaura Scardia , Claudia Acquafredda , Caterina Di Bella , Antonio Crovace , Luca Lacitignola , Pablo Otero , Francesco Staffieri

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引用次数: 0

Abstract

Objective

To evaluate the effectiveness, the time to restore normoxaemia (TRN), and the tolerability of face mask (FM), continuous-positive-airway-pressure helmet (CPAP), or high-flow nasal cannulae (HFNC) as noninvasive respiratory support strategies for treating transient postoperative hypoxaemia in dogs.

Study design

Prospective, randomized, clinical trial.

Animals

A total of 600 client owned dogs anaesthetized for various procedures.

Methods

At the end of general anaesthesia, the haemoglobin oxygen saturation (SpO₂) on room air (SpAT) was used for assessment of oxygenation 10 minutes after extubation (T-POST). Hypoxaemic dogs (SpO₂ < 95%) were randomly assigned to: FM-group [flow rate = 10 L minute^–1; fraction of inspired oxygen (FIO₂) = 0.3–0.4], CPAP-group (flow rate = 10 L minute^–1; FIO₂ = 0.3–0.4; CPAP = 5 cmH₂O), and HFNC-group (flow rate = 2–2.5 L kg^–1 minute^–1 at 37 °C; FIO₂ = 0.3–0.4). Treatments lasted 1 hour, divided into 15-minute intervals (T15, T30, T45, T60) with 10 minutes of treatment and 5 minutes of SpAT. The TRN during SpAT was recorded. Interface tolerance was assessed using a dedicated scale. SpO₂ and TRN were compared with two-way ANOVA, Kruskal–Wallis was used to test for differences in tolerance score between groups. p < 0.05.

Results

At T-POST, 168 dogs (28%) were hypoxaemic, and 76 of them completed the study (CPAP-group n = 31, FM-group n = 24, HFNC-group n = 21). All treatments restored normoxaemia. TRN was faster in the CPAP-group compared with HFNC-group and FM-group (mean ± standard deviation: 16.9 ± 15.7, 27.8 ± 20.8, and 40.4 ± 12.8 minutes, respectively) (p < 0.05). Tolerance was good for all devices, without differences between groups.

Conclusions and clinical relevance

Postoperative hypoxaemia in dogs can be effectively treated with FM, HFNC, or CPAP, the latter restoring normoxaemia more rapidly.

查看原文本刊更多论文

无创呼吸策略对狗术后低氧血症管理的有效性：一项前瞻性随机临床试验。

目的：评价面罩（FM）、持续气道正压头盔（CPAP）或高流量鼻插管（HFNC）作为无创呼吸支持策略治疗犬术后一过性低氧血症的有效性、恢复正常氧血症（TRN）的时间以及耐受性。研究设计：前瞻性、随机、临床试验。动物：总共有600只客户拥有的狗被麻醉进行各种手术。方法：全麻结束时，拔管后10分钟（T-POST）采用室内空气血红蛋白氧饱和度（SpO2）评价氧合情况。低氧血症（SpO2 < 95%）犬随机分为：fm组[流量= 10 L min -1；吸入氧分数(FIO2) = 0.3-0.4]、CPAP组（流量= 10 L min -1; FIO2 = 0.3-0.4; CPAP = 5 cmH2O）、hfnc组（37℃时流量= 2-2.5 L kg-1 min -1; FIO2 = 0.3-0.4）。治疗时间为1小时，每隔15分钟（T15、T30、T45、T60），治疗10分钟，痰液5分钟。记录了spv期间的TRN。使用专用刻度评估界面公差。SpO2和TRN比较采用双因素方差分析，耐受评分采用Kruskal-Wallis检验。P < 0.05。结果：T-POST时，168只狗（28%）出现低氧血症，其中76只完成了研究（cpap组n = 31， fm组n = 24， hfnc组n = 21）。所有治疗均恢复正常血氧。cpap组TRN较hfnc组、fm组更快（平均±标准差分别为16.9±15.7、27.8±20.8、40.4±12.8 min），差异有统计学意义（p < 0.05）。所有设备的耐受性都很好，各组之间没有差异。结论及临床意义：FM、HFNC或CPAP均可有效治疗犬术后低氧血症，且CPAP恢复正常氧血症更快。

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来源期刊

Veterinary anaesthesia and analgesia 农林科学-兽医学

CiteScore

3.10

自引率

17.60%

发文量

审稿时长

97 days

期刊介绍： Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome: the basic sciences; pathophysiology of disease as it relates to anaesthetic management equipment intensive care chemical restraint of animals including laboratory animals, wildlife and exotic animals welfare issues associated with pain and distress education in veterinary anaesthesia and analgesia. Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.