Bottle Gourd (Lagenaria siceraria): Novel Insights Into the Biochemical Propensities of the Unexplored Cultivar.

IF 3.6 Q2 BIOLOGY

Scientifica Pub Date : 2026-02-23 eCollection Date: 2026-01-01 DOI:10.1155/sci5/7463939

Hanan Y Aati, Renad Al-Arifi, Chitchamai Ovatlarnporn, Mohsin Abbas Khan, Abdul Rauf, Hossam M Hassan, Abdul Basit, Huma Rao, Laiba Rehman, Kashif Ur Rehman Khan

{"title":"Bottle Gourd (Lagenaria siceraria): Novel Insights Into the Biochemical Propensities of the Unexplored Cultivar.","authors":"Hanan Y Aati, Renad Al-Arifi, Chitchamai Ovatlarnporn, Mohsin Abbas Khan, Abdul Rauf, Hossam M Hassan, Abdul Basit, Huma Rao, Laiba Rehman, Kashif Ur Rehman Khan","doi":"10.1155/sci5/7463939","DOIUrl":null,"url":null,"abstract":"The fruit of Lagenaria siceraria (bottle gourd), widely consumed as a vegetable, possesses notable health benefits. This study investigated the chemical and biological profiles of the Saudi cultivar through quantitative bioactive analysis, GC-MS characterization, and in vitro evaluation of antioxidant, antibacterial, and enzyme inhibition activities. The 80% hydroethanolic extract (HEELS) exhibited a rich phytochemical profile, with the highest total tannin content (97.66 ± 3.33 mg/g). GC-MS identified 55 compounds, including fatty acids, esters, sterols, and triterpenoids. HEELS displayed potent antioxidant activity, particularly in the FRAP assay (582 ± 1.18 mg AAE/g DE), and strong urease inhibition (91.8 ± 0.45%). Antibacterial assays showed the highest activity (12-mm inhibition zone) against Staphylococcus epidermidis at 150 mg/mL. Molecular docking revealed significant interactions with α-amylase, urease, and tyrosinase. These results suggest HEELS as a potential therapeutic agent, warranting further pharmacological and toxicological evaluation to confirm safety and efficacy for clinical applications.","PeriodicalId":21726,"journal":{"name":"Scientifica","volume":"2026 ","pages":"7463939"},"PeriodicalIF":3.6000,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927919/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scientifica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/sci5/7463939","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The fruit of Lagenaria siceraria (bottle gourd), widely consumed as a vegetable, possesses notable health benefits. This study investigated the chemical and biological profiles of the Saudi cultivar through quantitative bioactive analysis, GC-MS characterization, and in vitro evaluation of antioxidant, antibacterial, and enzyme inhibition activities. The 80% hydroethanolic extract (HEELS) exhibited a rich phytochemical profile, with the highest total tannin content (97.66 ± 3.33 mg/g). GC-MS identified 55 compounds, including fatty acids, esters, sterols, and triterpenoids. HEELS displayed potent antioxidant activity, particularly in the FRAP assay (582 ± 1.18 mg AAE/g DE), and strong urease inhibition (91.8 ± 0.45%). Antibacterial assays showed the highest activity (12-mm inhibition zone) against Staphylococcus epidermidis at 150 mg/mL. Molecular docking revealed significant interactions with α-amylase, urease, and tyrosinase. These results suggest HEELS as a potential therapeutic agent, warranting further pharmacological and toxicological evaluation to confirm safety and efficacy for clinical applications.

查看原文本刊更多论文

葫芦（Lagenaria siceraria）：对未开发品种生化倾向的新见解。

葫芦（Lagenaria siceraria）的果实作为一种蔬菜被广泛食用，具有显著的健康益处。本研究通过定量生物活性分析、GC-MS表征以及体外抗氧化、抗菌和酶抑制活性评价，研究了沙特阿拉伯品种的化学和生物学特征。80%乙醇提取物（HEELS）具有丰富的植物化学特征，总单宁含量最高（97.66±3.33 mg/g）。GC-MS鉴定出55种化合物，包括脂肪酸、酯类、甾醇和三萜。高铁具有较强的抗氧化活性，特别是在FRAP实验中（582±1.18 mg AAE/g DE）和较强的脲酶抑制作用（91.8±0.45%）。抑菌实验表明，当浓度为150 mg/mL时，对表皮葡萄球菌的抑菌活性最高（12 mm抑制区）。分子对接发现与α-淀粉酶、脲酶和酪氨酸酶有显著的相互作用。这些结果表明，高铁是一种潜在的治疗药物，需要进一步的药理学和毒理学评价来确认临床应用的安全性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Scientifica BIOLOGY-

CiteScore

6.70

自引率

0.00%

发文量

审稿时长

21 weeks

期刊介绍： Scientifica is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies covering a wide range of subjects in the life sciences, environmental sciences, health sciences, and medicine. The journal is divided into the 65 subject areas.