Extracellular vesicle therapy for spinal cord injury: engineering-enhanced strategies and combination therapies.

IF 2.6 4区医学 Q4 CELL & TISSUE ENGINEERING

Regenerative medicine Pub Date : 2026-02-24 DOI:10.1080/17460751.2026.2636634

Lin Zhang, Linlin Dong, Zhongli Dong

引用次数: 0

Abstract

Spinal cord injury (SCI) is a highly disabling central nervous system disease. The prognosis of traditional treatment methods is poor at present, which is closely related to the poor regenerative ability of the nervous system. Extracellular vesicles (EVs) have shown excellent therapeutic potential because they restore immune homeostasis in the injured area, promoting axonal regeneration and angiogenesis. However, there are still many deficiencies in the use of extracellular vesicles alone. Researchers have significantly improved the therapeutic effect through many methods, such as engineering amplification strategies, intelligent delivery systems, and combined treatment with vesicle materials. In view of this, We conducted a search in the PubMed and Web of Science databases for articles published up to January 2026, and this article systematically reviews the research progress, mechanism of action, and frontier technology development of EVs in SCI, providing a theoretical basis and technical reference for regenerative medicine.

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脊髓损伤的细胞外囊泡治疗：工程增强策略和联合治疗。

脊髓损伤是一种高度致残的中枢神经系统疾病。目前传统治疗方法预后较差，这与神经系统再生能力差密切相关。细胞外囊泡（EVs）具有良好的治疗潜力，因为它们可以恢复损伤区域的免疫稳态，促进轴突再生和血管生成。然而，单独使用细胞外囊泡仍有许多不足之处。研究人员通过工程放大策略、智能给药系统、囊泡材料联合治疗等多种方法显著提高了治疗效果。鉴于此，我们检索了PubMed和Web of Science数据库截至2026年1月发表的文章，系统综述了SCI中ev的研究进展、作用机制和前沿技术发展，为再生医学提供理论基础和技术参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative medicine 医学-工程：生物医学

CiteScore

4.20

自引率

3.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Regenerative medicine replaces or regenerates human cells, tissue or organs, to restore or establish normal function*. Since 2006, Regenerative Medicine has been at the forefront of publishing the very best papers and reviews covering the entire regenerative medicine sector. The journal focusses on the entire spectrum of approaches to regenerative medicine, including small molecule drugs, biologics, biomaterials and tissue engineering, and cell and gene therapies – it’s all about regeneration and not a specific platform technology. The journal’s scope encompasses all aspects of the sector ranging from discovery research, through to clinical development, through to commercialization. Regenerative Medicine uniquely supports this important area of biomedical science and healthcare by providing a peer-reviewed journal totally committed to publishing the very best regenerative medicine research, clinical translation and commercialization. Regenerative Medicine provides a specialist forum to address the important challenges and advances in regenerative medicine, delivering this essential information in concise, clear and attractive article formats – vital to a rapidly growing, multidisciplinary and increasingly time-constrained community. Despite substantial developments in our knowledge and understanding of regeneration, the field is still in its infancy. However, progress is accelerating. The next few decades will see the discovery and development of transformative therapies for patients, and in some cases, even cures. Regenerative Medicine will continue to provide a critical overview of these advances as they progress, undergo clinical trials, and eventually become mainstream medicine.