Population-Based Structural Evidence: Triadic Effects of Periodontitis, Depression, and Biological Aging on Cognitive Health.

IF 3.1 3区医学 Q3 GERIATRICS & GERONTOLOGY

Gerontology Pub Date : 2026-01-01 Epub Date: 2026-02-24 DOI:10.1159/000551180

Dawei Zhang, Shijie Zhu, Zhaobiao Zong, Lijian Jin, Patrick Rijkschroeff

{"title":"Population-Based Structural Evidence: Triadic Effects of Periodontitis, Depression, and Biological Aging on Cognitive Health.","authors":"Dawei Zhang, Shijie Zhu, Zhaobiao Zong, Lijian Jin, Patrick Rijkschroeff","doi":"10.1159/000551180","DOIUrl":null,"url":null,"abstract":"Introduction: Cognitive impairment represents critical public health challenges in aging societies. This study investigated periodontitis, depression, and biological aging's triadic effects on cognition.Methods: Structural equation modeling (SEM) and relative weight analysis (RWA) were applied to analyze data from 2011 to 2014 National Health and Nutrition Examination Survey (NHANES) (N = 1,816). Cognitive function, periodontitis, depression, and biological age (PhenoAge) were assessed with covariates adjustment.Results: SEM revealed periodontitis severity, depressive symptoms, and PhenoAge advancement exhibited significant direct associations with lower cognitive performance after covariate adjustment. Simultaneously, biological aging partially mediated the influence of both depression and periodontitis on cognitive outcomes. RWA showed dominated cognitive variance, while periodontitis, depression, and PhenoAge contributed significantly.Conclusion: This supports triadic interdependencies where biological aging partially mediates the associations between periodontitis/depression and cognition. Prioritizing periodontal care and mental health may mitigate cognitive decline, especially in low-resource settings. .","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"343-353"},"PeriodicalIF":3.1000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075863/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gerontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000551180","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/24 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Cognitive impairment represents critical public health challenges in aging societies. This study investigated periodontitis, depression, and biological aging's triadic effects on cognition.

Methods: Structural equation modeling (SEM) and relative weight analysis (RWA) were applied to analyze data from 2011 to 2014 National Health and Nutrition Examination Survey (NHANES) (N = 1,816). Cognitive function, periodontitis, depression, and biological age (PhenoAge) were assessed with covariates adjustment.

Results: SEM revealed periodontitis severity, depressive symptoms, and PhenoAge advancement exhibited significant direct associations with lower cognitive performance after covariate adjustment. Simultaneously, biological aging partially mediated the influence of both depression and periodontitis on cognitive outcomes. RWA showed dominated cognitive variance, while periodontitis, depression, and PhenoAge contributed significantly.

Conclusion: This supports triadic interdependencies where biological aging partially mediates the associations between periodontitis/depression and cognition. Prioritizing periodontal care and mental health may mitigate cognitive decline, especially in low-resource settings.

查看原文本刊更多论文

基于人群的结构证据：牙周炎、抑郁和生物衰老对认知健康的三重影响。

引言：认知障碍是老龄化社会中重要的公共卫生挑战。本研究探讨牙周炎、抑郁和生物老化对认知的三合一影响。方法：采用结构方程模型（SEM）和相对权重分析（RWA）对2011-2014年全国健康与营养检查调查（NHANES）（N=1,816）的数据进行分析。认知功能、牙周炎、抑郁和生物年龄（PhenoAge）通过协变量调整进行评估。结果：经协变量调整后，扫描电镜显示牙周炎的严重程度、抑郁症状和表型进展与较低的认知表现有显著的直接关联。同时，生物老化部分介导了抑郁症和牙周炎对认知结果的影响。RWA以认知差异为主，而牙周炎、抑郁和表型差异显著。结论：这证实了生物衰老部分介导牙周炎/抑郁对认知的影响的三位一体相互依赖性。优先考虑牙周保健和心理健康可以减轻认知能力下降，特别是在资源匮乏的环境中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Gerontology 医学-老年医学

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.