Natural Product-Based Therapeutic Strategies Targeting Signaling Pathways in Prostate Cancer: A Comprehensive Review.

IF 2.5 4区医学 Q3 ONCOLOGY

Current cancer drug targets Pub Date : 2026-02-19 DOI:10.2174/0115680096404959251120100154

Riya Chaudhary, Arbab Husain, Afreen Khanam, Pratibha Pandey, Fahad Khan

{"title":"Natural Product-Based Therapeutic Strategies Targeting Signaling Pathways in Prostate Cancer: A Comprehensive Review.","authors":"Riya Chaudhary, Arbab Husain, Afreen Khanam, Pratibha Pandey, Fahad Khan","doi":"10.2174/0115680096404959251120100154","DOIUrl":null,"url":null,"abstract":"<p><p>Prostate Cancer (PCa) remains one of the leading causes of cancer-related death among men globally. While numerous traditional treatments like chemotherapy, radiation ther-apy, and surgical procedures exist, they often exhibit challenges due to drug resistance mech-anisms, off-target effects, and severe toxicity to normal tissues. Hence, finding other low-tox-icity therapeutic methods is of utmost importance. This review summarizes the ability of nat-ural product-derived therapies to target critical signaling pathways involved in PCa progres-sion, including the Androgen Receptor (AR), PI3K/AKT/mTOR, JAK/STAT, MAPK, and NF-κB pathways. Curcumin, resveratrol, genistein, and sulforaphane are natural compounds that exhibit anticancer effects by regulating these molecular pathways, thereby inhibiting tu-mor growth, inducing apoptosis, and preventing metastasis. By critically evaluating recent trends and comparing findings with current research, this review highlights the therapeutic value of these bioactive compounds. Additionally, the review discusses current knowledge gaps and proposes future research directions to optimize natural product-based interventions for PCa management.</p>","PeriodicalId":10816,"journal":{"name":"Current cancer drug targets","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current cancer drug targets","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680096404959251120100154","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Prostate Cancer (PCa) remains one of the leading causes of cancer-related death among men globally. While numerous traditional treatments like chemotherapy, radiation ther-apy, and surgical procedures exist, they often exhibit challenges due to drug resistance mech-anisms, off-target effects, and severe toxicity to normal tissues. Hence, finding other low-tox-icity therapeutic methods is of utmost importance. This review summarizes the ability of nat-ural product-derived therapies to target critical signaling pathways involved in PCa progres-sion, including the Androgen Receptor (AR), PI3K/AKT/mTOR, JAK/STAT, MAPK, and NF-κB pathways. Curcumin, resveratrol, genistein, and sulforaphane are natural compounds that exhibit anticancer effects by regulating these molecular pathways, thereby inhibiting tu-mor growth, inducing apoptosis, and preventing metastasis. By critically evaluating recent trends and comparing findings with current research, this review highlights the therapeutic value of these bioactive compounds. Additionally, the review discusses current knowledge gaps and proposes future research directions to optimize natural product-based interventions for PCa management.

查看原文本刊更多论文

针对前列腺癌信号通路的天然产物治疗策略：综述

前列腺癌仍然是全球男性癌症相关死亡的主要原因之一。虽然存在许多传统治疗方法，如化疗、放射治疗和外科手术，但由于耐药机制、脱靶效应和对正常组织的严重毒性，它们经常表现出挑战。因此，寻找其他低毒性的治疗方法至关重要。本文综述了天然产物衍生疗法靶向PCa进展过程中关键信号通路的能力，包括雄激素受体（AR）、PI3K/AKT/mTOR、JAK/STAT、MAPK和NF-κB通路。姜黄素、白藜芦醇、染料木素和萝卜硫素是通过调节这些分子通路来表现抗癌作用的天然化合物，从而抑制肿瘤生长、诱导细胞凋亡和防止转移。通过批判性地评估最近的趋势，并与目前的研究结果进行比较，本综述强调了这些生物活性化合物的治疗价值。此外，本文还讨论了目前的知识差距，并提出了未来的研究方向，以优化PCa管理中基于天然产物的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current cancer drug targets 医学-肿瘤学

CiteScore

5.40

自引率

0.00%

发文量

105

审稿时长

1 months

期刊介绍： Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.