Obesity and Weight Management in HIV: Epidemiology, Complications, and Emerging Treatments.

IF 4.4 2区医学 Q2 INFECTIOUS DISEASES

Current HIV/AIDS Reports Pub Date : 2026-02-24 DOI:10.1007/s11904-026-00776-1

Luke Pryke, John R Koethe, Samuel Bailin

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Abstract

Purpose of review: People living with HIV (PLWH) on contemporary antiretroviral therapy experience high rates of overweight/obesity, which predisposes to cardiometabolic disease and multiple other conditions with negative health consequences in this aging population. We aim to summarize the epidemiology and pathophysiology of obesity in PLWH and review recent advances in the therapeutic management of obesity.

Recent findings: The prevalence of overweight/obesity in PLWH mirrors long-standing trends in the general population. Obesity and weight gain have a complex, multifactorial pathogenesis and directly mediate detrimental metabolic changes that are common in PLWH. While lifestyle changes are important, surgical weight loss and recent advances in medical therapeutics are more effective at reducing obesity and obesity-related complications. Obesity in PLWH substantially increases the risk for cardiometabolic complications and poor health outcomes. Surgical and medical weight loss interventions are effective treatments to reduce obesity and obesity-related complications, though further research in PLWH is needed to define optimal management.

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HIV的肥胖和体重管理：流行病学、并发症和新兴治疗方法。

综述的目的：接受当代抗逆转录病毒治疗的艾滋病毒感染者（PLWH）超重/肥胖的比例很高，这在这一老龄化人群中容易患心脏代谢疾病和多种其他对健康有负面影响的疾病。我们旨在总结PLWH肥胖的流行病学和病理生理学，并回顾肥胖症治疗管理的最新进展。最近的发现：PLWH中超重/肥胖的流行反映了一般人群的长期趋势。肥胖和体重增加具有复杂的多因素发病机制，并直接介导PLWH中常见的有害代谢变化。虽然生活方式的改变很重要，但手术减肥和医学治疗的最新进展在减少肥胖和肥胖相关并发症方面更为有效。PLWH患者的肥胖显著增加了心脏代谢并发症和不良健康结果的风险。手术和药物减肥干预是减少肥胖和肥胖相关并发症的有效治疗方法，但需要对PLWH进行进一步研究以确定最佳管理方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current HIV/AIDS Reports INFECTIOUS DISEASES-

CiteScore

8.10

自引率

2.20%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of HIV/AIDS. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antiretroviral therapies, behavioral aspects of management, and metabolic complications and comorbidity. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.