Saskia Herges, Hannah Ohrem, René Dörfelt, Florian Sänger
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引用次数: 0
Abstract
Objective: To evaluate hematological changes in dogs with acute kidney injury caused by different underlying disease processes treated with intermittent hemodialysis (IHD) over 12 to 24 hours after the session.
Methods: Client-owned dogs with acute kidney injury treated with IHD from February 2021 through July 2025 were prospectively enrolled in this observational study. Blood was collected from each dog before IHD (T0), after IHD (T1), and 12 to 24 hours after IHD (T2). Hematocrit, RBC count, hemoglobin concentration, reticulocyte count, platelet count, and WBC count were evaluated at all time points.
Results: In total, 30 dogs with 82 IHD sessions were included in the study. Median RBC count (X 1012/L) and median hemoglobin concentration (mmol/L) decreased from 4.00 (2.82 to 7.22) and 9.25 (6.60 to 17.20) at T0 to 3.74 (2.39 to 7.04) and 9.00 (5.50 to 16.80) at T1, respectively. Median WBC count (X 109/L) of 19.34 (6.49 to 55.47) at T0 decreased to 17.6 (4.57 to 73.22) at T1 and increased to 20.11 (7.48 to 55.47) at T2. Median platelet count (X 109/L) of 99 (5 to 767) at T0 decreased to 69 (1 to 633) at T1 and increased to 84 (4 to 604) at T2.
Conclusions: Hematological changes during IHD were mild and transient. Only the platelet count decreased moderately.
Clinical relevance: Most of the hematological changes did not appear clinically relevant and resolved within 24 hours. However, the moderate decrease in platelet count could potentially predispose dogs undergoing IHD to an increased risk of bleeding.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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