Jamie S F Lemus, Barbara Delvescovo, Elizabeth Williams Louie, Stephen Parry, Stephanie A Hon, Marta Cercone, Rebecca C McOnie
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引用次数: 0
Abstract
Objective: To compare creatinine concentrations measured using a point-of-care unit (Nova StatSensor; NSS) to those from a comparison method (CM) chemistry analyzer from pigs presented at a referral institution.
Methods: A clinical prospective study was performed including 61 pigs admitted to Cornell Nemo Farm Animal Hospital for clinical reasons. Heparinized blood samples were obtained by venous aspiration, and whole-blood samples were obtained via ear prick. Creatinine concentrations were subsequently measured in triplicate on the NSS (on heparinized venous samples [NSSven] and ear prick samples [NSSear]) and compared to the CM. Paired t tests and intraclass correlation coefficients were performed. A Bland-Altman plot was graphed based on a linear mixed-effects model to estimate agreement between tests. Equivalence testing was performed.
Results: NSSven (n = 110) and NSSear (71) from 61 nonazotemic pigs were analyzed. The mean creatinine ± SD was 1.3 ± 0.52 mg/dL from the CM, 1.1 ± 0.43 mg/dL from the NSSven, and 1.2 ± 0.42 mg/dL from the NSSear. Bias existed between average NSSven (-0.17 mg/dL) and NSSear (-0.21 mg/dL) and the CM. The 95% CI of the limit of agreement between the NSSven and CM was -0.88 to 0.54 and -1.04 to 0.62 between the NSSear and CM. The tests were not equivalent at 0.3 mg/dL.
Conclusions: The NSSven, NSSear, and CM results are different and not equivalent in nonazotemic pigs.
Clinical relevance: The use of this device for screening of creatinine in pigs is discouraged based on the results in this population.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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