24-month single-pill, triple antihypertensive therapy in rural Rwanda.

IF 2.3 4区医学

Blood Pressure Pub Date : 2026-12-01 Epub Date: 2026-03-02 DOI:10.1080/08037051.2026.2635838

Isabella Hunjan, Clara Stroppa, Alice Umulisa, Gianfranco Parati, Mario G Bianchetti, Bienvenu Muvunyi, Willy Mucyo, Evariste Ntaganda, Sebastiano A G Lava, Franco Muggli

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引用次数: 0

Abstract

Introduction: Arterial hypertension is a leading modifiable cardiovascular risk factor. Recent guidelines recommend single-pill, low-dose combinations as initial pharmacological strategy. We investigated the long-term feasibility and sustained effect of such a strategy in a remote rural area of Southern Rwanda, in sub-Saharan Africa.

Methods: Hypertension was diagnosed using three sets of blood pressure measurements obtained according to European Society of Hypertension recommendations using a validated oscillometric device (OMRON M7 IT-HEM-7322-E). Individuals meeting diagnostic criteria were initiated on a single-pill combination of amlodipine, hydrochlorothiazide, and olmesartan. Treatment dosage was reassessed and adjusted as needed at each outpatient clinic visit.

Results: Fifty-seven Black African participants with confirmed uncomplicated, untreated hypertension (aged 65 [54-70] years; median and interquartile range) had follow-up data available for up to 24 months after inclusion. Blood pressure <140/90 mm Hg was achieved in 37 (65%) participants after 1 month, 51 (89%) after 3 months, 44 (77%) after 6 months, 43 (75%) after 12 months, and 47 (83%) after 24 months.

Conclusion: Long-term management of arterial hypertension with a once-daily single-pill combination of amlodipine, hydrochlorothiazide, and olmesartan as initial therapy is feasible in a rural sub-Saharan African setting. Blood pressure reduction is sustained for at least 24 months. Single-pill combinations should be made accessible even in remote areas of low- and middle-income countries.

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卢旺达农村24个月单片三联抗高血压治疗。

简介：动脉高血压是一个主要的可改变的心血管危险因素。经过修改后，最近的指南推荐单丸低剂量联合用药作为初始药理学策略。我们在撒哈拉以南非洲的卢旺达南部偏远农村地区调查了这种战略的长期可行性和持续效果。方法：根据欧洲高血压学会的建议，使用经过验证的振荡测量仪（OMRON M7 IT-HEM-7322-E），使用三组血压测量结果诊断动脉高血压。符合诊断标准的个体开始使用氨氯地平、氢氯噻嗪和奥美沙坦的单片组合。在每次门诊就诊时重新评估和调整治疗剂量。结果：57名确诊无并发症且未经治疗的非洲黑人高血压患者（年龄65[54-70]岁，中位数和四分位数范围）在纳入后随访数据可达24个月。结论：在撒哈拉以南非洲农村地区，每日一次的氨氯地平、氢氯噻嗪和奥美沙坦联合单片治疗动脉高血压是可行的。血压降低至少持续24个月。即使在低收入和中等收入国家的偏远地区，也应提供单片组合药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Pressure Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.20

自引率

5.60%

发文量

期刊介绍： For outstanding coverage of the latest advances in hypertension research, turn to Blood Pressure, a primary source for authoritative and timely information on all aspects of hypertension research and management. Features include: • Physiology and pathophysiology of blood pressure regulation • Primary and secondary hypertension • Cerebrovascular and cardiovascular complications of hypertension • Detection, treatment and follow-up of hypertension • Non pharmacological and pharmacological management • Large outcome trials in hypertension.