Chromatin loop proteomics finds a non-catalytic function for a histone demethylase

IF 29 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2026-02-24 DOI:10.1038/s41588-026-02519-9

Viviana I. Risca

引用次数: 0

Abstract

In this issue, Jiang et al. introduce a proteomic method called LoopID and show that JMJD2 demethylases have a non-catalytic role in promoting enhancer–promoter looping in mouse embryonic stem cells. This function is mediated by their intrinsically disordered domains, suggesting a condensate-based mechanism.

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染色质环蛋白质组学发现组蛋白去甲基化酶的非催化功能

在本期中，Jiang等人介绍了一种名为LoopID的蛋白质组学方法，并表明JMJD2去甲基化酶在小鼠胚胎干细胞中促进增强子-启动子环具有非催化作用。这种功能是由它们的内在无序结构域介导的，表明这是一种基于凝聚物的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution