Urine as a non-invasive alternative for HPV DNA detection: A comparative study with cervical swabs in Northeast India

IF 1.3 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2026-03-01 Epub Date: 2026-02-21 DOI:10.1016/j.ijmmb.2026.101081

Biswajyoti Borkakoty , Nargis K. Bali , Munmun Gohain , Mousumi Dutta , Sobnom Gogoi , Pesona Grace Lucksom , Jaharlal Baidya , Tapan Mazumdar , Catherine Manguri , Basumoti Apum , Paresh Shyam , Harpreet Kaur

引用次数: 0

Abstract

This study assessed urine as a non-invasive alternative to cervical swabs for human papillomavirus (HPV) DNA detection using nested PCR in 350 paired samples from women across five Northeastern Indian states. HPV DNA was found in 27.4% of urine and 38.3% of cervical swabs, with 21.1% concordant positives. Urine identified 22 additional positives missed by swabs, while 60 were swab-only. Using cervical swabs as the reference, urine showed 55.2% sensitivity, 89.8% specificity, and moderate concordance (κ = 0.48). Despite modest sensitivity, urine sampling may serve as a feasible, culturally acceptable adjunct for HPV screening in under-screened populations.

查看原文本刊更多论文

尿液作为HPV DNA检测的非侵入性替代：与印度东北部宫颈拭子的比较研究。

这项研究评估了尿液作为宫颈拭子检测人类乳头瘤病毒（HPV） DNA的非侵入性替代方法，使用巢式PCR对来自印度东北部5个邦的350对女性样本进行了检测。在27.4%的尿液和38.3%的宫颈拭子中发现HPV DNA，其中21.1%的一致性阳性。另外22例尿检阳性未被拭子检出，60例仅为拭子检出。以宫颈拭子作为对照，尿液的敏感性为55.2%，特异性为89.8%，一致性中等（κ=0.48）。尽管敏感性不高，但尿液取样可以作为一种可行的、文化上可接受的辅助手段，用于未筛查人群的HPV筛查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.