The relationship between MMP-2 and TIMP-2 gene polymorphisms and skin barrier function, inflammatory cytokine levels in acne patients.

IF 4 3区医学 Q2 IMMUNOLOGY

Expert Review of Clinical Immunology Pub Date : 2026-02-01 Epub Date: 2026-03-04 DOI:10.1080/1744666X.2026.2636646

Suling Huang, Lijia Fang, Meina Zhang, Shuxian Sun, Huixian Zhi, Yuguang Zhu, Hong Zhang

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引用次数: 0

Abstract

Objective: This study aimed to investigate the association between MMP-2 rs243865 and TIMP-2 rs8179090 gene polymorphisms and skin barrier function, as well as inflammatory cytokine levels, in acne patients, to explore potential genetic mechanisms underlying acne pathogenesis.

Methods: A total of 200 acne patients and 100 healthy controls were enrolled. Genotyping was performed using PCR-RFLP. Skin barrier function was assessed via transepidermal water loss (TEWL) and hydration measurements. Serum levels of IL-1β and TNF-α were quantified by ELISA. Statistical analyses included Pearson correlation and logistic regression.

Results: The MMP-2-CC and TIMP-2-CC genotypes were significantly more prevalent in acne patients (p < 0.05). These genotypes correlated with higher TEWL (p < 0.05), reduced skin hydration (p < 0.05), and elevated IL-1β and TNF-α levels (p < 0.05) compared to CT/TT genotypes. Logistic regression confirmed associations between CC genotypes and increased acne severity (OR = 1.86-2.24).

Conclusion: The MMP-2 and TIMP-2 CC genotypes are linked to impaired skin barrier function and heightened inflammation in acne, suggesting their role in genetic susceptibility and disease progression. These findings may inform future targeted therapies.

Clinical trial registration: www.clinicaltrials.gov identifier is NCT07069075.

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痤疮患者MMP-2和TIMP-2基因多态性与皮肤屏障功能、炎性细胞因子水平的关系

目的：研究痤疮患者MMP-2 rs243865和TIMP-2 rs8179090基因多态性与皮肤屏障功能及炎症细胞因子水平的关系，探讨痤疮发病的潜在遗传机制。方法：选取200例痤疮患者和100例健康对照者。采用PCR-RFLP进行基因分型。通过经皮失水（TEWL）和水化测量来评估皮肤屏障功能。ELISA法测定血清IL-1β、TNF-α水平。统计分析包括Pearson相关和logistic回归。结果：MMP-2-CC和TIMP-2-CC基因型在痤疮患者中更为普遍（p p p p p）结论：MMP-2和TIMP-2 CC基因型与痤疮患者皮肤屏障功能受损和炎症加剧有关，提示其在遗传易感性和疾病进展中起作用。这些发现可能为未来的靶向治疗提供信息。临床试验注册：http://www.clinicaltrials.gov标识符：NCT07069075。

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来源期刊

Expert Review of Clinical Immunology IMMUNOLOGY-

CiteScore

7.60

自引率

2.30%

发文量

221

审稿时长

6-12 weeks

期刊介绍： Expert Review of Clinical Immunology (ISSN 1744-666X) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology. Members of the International Editorial Advisory Panel of Expert Review of Clinical Immunology are the forefront of their area of expertise. This panel works with our dedicated editorial team to identify the most important and topical review themes and the corresponding expert(s) most appropriate to provide commentary and analysis. All articles are subject to rigorous peer-review, and the finished reviews provide an essential contribution to decision-making in clinical immunology. Articles focus on the following key areas: • Therapeutic overviews of specific immunologic disorders highlighting optimal therapy and prospects for new medicines • Performance and benefits of newly approved therapeutic agents • New diagnostic approaches • Screening and patient stratification • Pharmacoeconomic studies • New therapeutic indications for existing therapies • Adverse effects, occurrence and reduction • Prospects for medicines in late-stage trials approaching regulatory approval • Novel treatment strategies • Epidemiological studies • Commentary and comparison of treatment guidelines Topics include infection and immunity, inflammation, host defense mechanisms, congenital and acquired immunodeficiencies, anaphylaxis and allergy, systemic immune diseases, organ-specific inflammatory diseases, transplantation immunology, endocrinology and diabetes, cancer immunology, neuroimmunology and hematological diseases.