Obesity as a shared risk factor in periodontitis and rheumatoid arthritis: Systematic review and meta-analysis.

IF 1.3 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Community dental health Pub Date : 2026-02-23 DOI:10.1177/0265539X261429990

Aimen Batool, Norul Husna M Hassan, Nazurah N Eezammuddeen, Syarida H Safii, Roslan Saub, Rathna D Vaithilingam

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引用次数: 0

Abstract

Aims: Studies have investigated the interrelationship between periodontitis (PD) and rheumatoid arthritis (RA). However, obesity, a risk factor common between both conditions requires further investigation. Therefore, the objective of this study was to pool evidence on whether concurrent RA and PD (RAPD) are associated with high Body Mass Index (BMI) compared to non-RAPD individuals. Methods: Systematic review conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines with the protocol registered with the International Prospective Register of Systematic Reviews. Embase, Medline, Web of Science and the Cochrane Library were accessed for relevant literature. The Newcastle-Ottawa scale was used to assess risk of bias among each study. Meta-analysis was performed using Revman statistical software. The effect size was measured using mean difference with 95% confidence intervals and a p-value of 0.05. Results: The search identified 770 articles. Following screening of title with abstracts and full text assessment, nine studies, involving 86,137 participants were included. Seven studies reported low to moderate risk of bias. In meta-analysis BMI was higher in people with RAPD than non-RAPD (MD = 0.56; Z = 2.06; p = 0.04). Conclusion: The correlation between high BMI and RAPD underscores a potential interplay between periodontal health and inflammatory diseases like obesity and RA. Thus, observational studies are warranted.

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肥胖是牙周炎和类风湿关节炎的共同危险因素：系统回顾和荟萃分析。

目的：研究牙周炎（PD）与类风湿关节炎（RA）之间的相互关系。然而，肥胖是这两种疾病共同的危险因素，需要进一步调查。因此，本研究的目的是收集与非RAPD个体相比，并发RA和PD （RAPD）是否与高体重指数（BMI）相关的证据。方法：根据系统评价和荟萃分析指南的首选报告项目进行系统评价，并在国际前瞻性系统评价登记册上注册。通过Embase、Medline、Web of Science和Cochrane Library检索相关文献。纽卡斯尔-渥太华量表用于评估每项研究的偏倚风险。采用Revman统计软件进行meta分析。效应量采用95%置信区间的均值差测量，p值为0.05。结果：检索出770篇文章。在对标题进行摘要筛选和全文评估后，纳入了9项研究，涉及86137名参与者。七项研究报告了低至中等偏倚风险。在荟萃分析中，RAPD患者的BMI高于非RAPD患者（MD = 0.56; Z = 2.06; p = 0.04）。结论：高BMI与RAPD之间的相关性强调了牙周健康与炎症性疾病（如肥胖和RA）之间的潜在相互作用。因此，观察性研究是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Community dental health 医学-牙科与口腔外科

CiteScore

2.20

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is concerned with dental public health and related subjects. Dental public health is the science and the art of preventing oral disease, promoting oral health, and improving the quality of life through the organised efforts of society. The discipline covers a wide range and includes such topics as: -oral epidemiology- oral health services research- preventive dentistry - especially in relation to communities- oral health education and promotion- clinical research - with particular emphasis on the care of special groups- behavioural sciences related to dentistry- decision theory- quality of life- risk analysis- ethics and oral health economics- quality assessment. The journal publishes scientific articles on the relevant fields, review articles, discussion papers, news items, and editorials. It is of interest to dentists working in dental public health and to other professionals concerned with disease prevention, health service planning, and health promotion throughout the world. In the case of epidemiology of oral diseases the Journal prioritises national studies unless local studies have major methodological innovations or information of particular interest.