Regional Cerebellar Volumetrics in Obsessive-Compulsive Disorder: An ENIGMA-OCD Study

IF 4.9 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Pub Date : 2026-10-01 Epub Date: 2026-02-20 DOI:10.1016/j.bpsc.2026.02.006

Srinivas Balachander, Janardhanan C. Narayanaswamy, Venkataram Shivakumar, Yoshinari Abe, Pino Alonso, Lea L. Backhausen, Nerisa Banaj, Marcelo C. Batistuzzo, Francesco Benedetti, Irene Bollettini, Beatrice Bravi, Silvia Brem, Carolina Cappi, Ritu Bhusal Chhatkuli, Sunah Choi, Patrícia Coelho, Ana Daniela Costa, Sara Dallaspezia, Damiaan Denys, Juliana B. Diniz, Y.C. Janardhan Reddy

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引用次数: 0

Abstract

Background

Although subtle differences in cortico-striato-thalamo-cortical circuit structure and function are critical to the current understanding of the neurocircuitry in obsessive-compulsive disorder (OCD), emerging evidence suggests that the cerebellum may also be involved. However, much of this evidence comes from studies with small samples and notable methodological heterogeneity.

Methods

We conducted a mega-analysis of individual-participant data on cerebellar subregional volumes, comparing individuals with OCD and healthy controls (HCs) from the ENIGMA-OCD Working Group. Three-dimensional T1-weighted volumetric structural brain magnetic resonance imaging (MRI) scans from 1954 individuals with OCD and 2091 HCs across 22 sites (40 datasets) were processed using the ACAPULCO (Automatic Cerebellum Anatomical parcellation using U-Net Locally Constrained Optimization) pipeline to extract cerebellar parcellations. We harmonized the volume measures across sites using the ComBat algorithm. Multiple linear regression models were fitted to estimate group differences separately within the pediatric (<12 years), adolescent (12–17 years), and adult (from 18 years) samples, adjusting for age, gender, and intracranial volume.

Results

In adults with OCD (vs. HCs), we found significantly smaller volumes of the corpus medullare (d = −0.093, false discovery rate (FDR)–corrected p = .036), left VIIb (d = −0.085, p_FDR = .039) and right VIIb (d = −0.091, p_FDR = .036). None of the comparisons between children or adolescents with OCD versus HCs remained statistically significant after FDR correction. In all 3 age groups, cerebellar (subregional) volumes were significantly moderated by medication status.

Conclusions

We report novel findings implicating specific cerebellar subregions across developmental stages of OCD and the key impact of medication status. Additional research on the functional significance of these findings may offer new translational leads.

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强迫症的区域小脑容量：一项ENIGMA-OCD研究。

背景：尽管皮质-纹状体-丘脑-皮质（CTSC）回路结构和功能的细微差异对当前对强迫症（OCD）神经回路的理解至关重要，但新出现的证据表明小脑也可能参与其中。然而，这些证据大多来自小样本研究和显著的方法异质性。方法:我们对个体参与者的小脑次区域容量数据进行了大规模分析，使用ACAPULCO（使用U-Net局部约束优化的自动小脑解剖分割）流水线对来自22个地点（40个数据集）的1,954名强迫症患者和2,091名HC患者进行3D t1加权体积结构脑磁共振成像（MRI）扫描，以提取小脑分割。我们使用ComBat算法协调了各个站点的体积测量。我们拟合了多元线性回归模型，分别估计了儿童的组间差异(结果：强迫症成人（与HC相比），我们发现髓体体积明显较小（d=-0.093, pfdr=0.036），左侧VIIb （d=-0.085, pfdr=0.039）和右侧VIIb （d= -0.091, pfdr=0.036）。在FDR校正后，儿童或青少年强迫症与HC之间的比较没有统计学意义。在所有三个年龄组中，小脑（分区域）体积因药物状况而显著降低。结论：我们报告了新的发现，涉及强迫症发展阶段的特定小脑亚区，以及药物状况的关键影响。进一步研究这些发现的功能意义可能会提供新的翻译线索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Neuroscience-Biological Psychiatry

CiteScore

10.40

自引率

1.70%

发文量

247

审稿时长

30 days

期刊介绍： Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is an official journal of the Society for Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal focuses on studies using the tools and constructs of cognitive neuroscience, including the full range of non-invasive neuroimaging and human extra- and intracranial physiological recording methodologies. It publishes both basic and clinical studies, including those that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The journal publishes novel results of original research which represent an important new lead or significant impact on the field. Reviews and commentaries that focus on topics of current research and interest are also encouraged.