Sex Difference Has No Effect on Survival in Pancreatic Cancer.

IF 0.7 Q4 ONCOLOGY

Indian Journal of Surgical Oncology Pub Date : 2026-02-01 Epub Date: 2025-05-07 DOI:10.1007/s13193-025-02321-9

Faruk Tas, Kayhan Erturk

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引用次数: 0

Abstract

Due to controversial results, the clinical impact of sex in pancreatic cancer has not been fully clarified. We aimed to investigate the clinical significance of sex in patients with pancreatic cancer in this study. A total of 334 pancreatic cancer patients were assessed retrospectively. Of 334 patients, 109 (32.6%) were women. The distribution of sex according to stages was identical: 52 of 154 patients (33.8%) had metastatic disease, 39 of 122 patients (32.0%) had locally advanced disease, and 18 of 58 patients (31.0%) had local disease (p = 0.9). No significant effect of any clinical variable on sex was observed in all stages, but women had higher serum LDH levels than men in metastatic disease (57.1 vs 20.5%, p = 0.009). Overall survival rates of patients in all stages were similar between sexes; the median overall survival rates in women vs. men were 5.5 vs. 4.35 months, respectively, in patients with metastatic disease (p = 0.2); 9.9 vs. 8.9 months, respectively in patients with locally advanced disease (p = 0.6); and 20.05 vs 17.8 months, respectively, in patients with local disease (p = 0.09). In conclusion, no effect of sex on survival was found in pancreatic cancer patients.

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性别差异对胰腺癌患者生存无影响。

由于有争议的结果，性别在胰腺癌中的临床影响尚未完全澄清。本研究旨在探讨胰腺癌患者性别差异的临床意义。对334例胰腺癌患者进行回顾性评估。334例患者中，109例（32.6%）为女性。根据分期的性别分布相同：154例患者中有52例（33.8%）有转移性疾病，122例患者中有39例（32.0%）有局部晚期疾病，58例患者中有18例（31.0%）有局部疾病（p = 0.9）。在所有阶段均未观察到任何临床变量对性别的显著影响，但在转移性疾病中，女性血清LDH水平高于男性（57.1 vs 20.5%, p = 0.009）。所有阶段患者的总生存率在性别之间相似；在转移性疾病患者中，女性和男性的中位总生存率分别为5.5个月和4.35个月（p = 0.2）；局部晚期患者分别为9.9个月和8.9个月（p = 0.6）；局部病变患者分别为20.05个月和17.8个月（p = 0.09）。总之，性别对胰腺癌患者的生存没有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Surgical Oncology ONCOLOGY-

CiteScore

1.10

自引率

0.00%

发文量

190

期刊介绍： The Indian Journal of Surgical Oncology aims to encourage and promote clinical and research activities pertaining to Surgical Oncology. It also aims to bring in the concept of multidisciplinary team approach in management of various cancers. The Journal would publish original article, point of technique, review article, case report, letter to editor, profiles of eminent teachers, surgeons and instititions - a short (up to 500 words) of the Cancer Institutions, departments, and oncologist, who founded new departments.