The Role of Chronopsychiatry in Precision Medicine: Circadian Dysregulation as Diagnostic Marker and Therapeutic Target.

IF 2 Q4 CLINICAL NEUROLOGY

Current Sleep Medicine Reports Pub Date : 2026-01-01 Epub Date: 2026-02-20 DOI:10.1007/s40675-026-00357-z

Aswathy B Suseela Devi, Katherine Lyman, Colleen A McClung

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Abstract

Purpose of review: Chronopsychiatry refers to a research and clinical approach which studies psychiatric illness through the lens of circadian rhythms and aims to reset the body's biological clock to counteract circadian rhythm abnormalities in psychiatric disorders. This review highlights the use of circadian biomarkers collected from wearable devices and other methods to help the development of personalized treatment plans based on patients' individual circadian functioning. Circadian biomarkers, such as activity, heart rate, skin temperature, and light exposure recorded over 24 h, has shown promise in diagnosing and assessing the severity of various neuropsychiatric disorders.

Recent findings: Wearable devices capable of recording multiple circadian parameters have greatly aided data collection, and when integrated into treatment, have shown promise for revolutionizing circadian medicine. Therapies that entrain or shift the circadian system can help stabilize sleep-wake rhythms or better align rhythms with the environment.

Summary: These approaches support the emerging field of precision psychiatry, moving beyond a one-size-fits-all approach and addressing the heterogeneity and complexity of psychiatric disorders.

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时间精神病学在精准医学中的作用：昼夜节律失调作为诊断标志和治疗靶点。

综述目的：时间精神病学是指通过昼夜节律的角度来研究精神疾病的一种研究和临床方法，旨在重置人体的生物钟，以抵消精神疾病的昼夜节律异常。这篇综述强调了从可穿戴设备和其他方法收集的昼夜节律生物标志物的使用，以帮助制定基于患者个体昼夜节律功能的个性化治疗计划。昼夜生物标志物，如24小时内记录的活动、心率、皮肤温度和光照，在诊断和评估各种神经精神疾病的严重程度方面显示出了希望。最近的发现：能够记录多个昼夜节律参数的可穿戴设备极大地帮助了数据收集，并且当集成到治疗中时，已经显示出革命性的昼夜节律医学的希望。引导或改变昼夜节律系统的疗法可以帮助稳定睡眠-觉醒节奏，或更好地使节奏与环境保持一致。总结：这些方法支持了精确精神病学的新兴领域，超越了一刀切的方法，并解决了精神疾病的异质性和复杂性。

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来源期刊

Current Sleep Medicine Reports Medicine-Pulmonary and Respiratory Medicine

CiteScore

2.50

自引率

5.60%

发文量

期刊介绍： Current Sleep Medicine Reports aims to review the most important, recently published articles in the field of sleep medicine. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of sleep conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as insomnia, narcolepsy, sleep apnea, circadian rhythm disorders, and parasomnias. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.