Comparative Evaluation of Topical Stabilized Retinaldehyde 0.1% vs. 0.05% on Skin Biophysical and Biomechanical Parameters.

IF 2.8 4区医学 Q3 DERMATOLOGY

Skin Research and Technology Pub Date : 2026-02-01 DOI:10.1111/srt.70326

Anna Deda, Wiktoria Odrzywołek, Agata Lebiedowska, Anna Banyś, Małgorzata Bożek, Dagmara Kuca, Nina Wiśniewska, Dominika Wcisło-Dziadecka, Sławomir Wilczyński

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引用次数: 0

Abstract

Background: The aim of this study was to evaluate the biophysical and biomechanical effects of topical stabilized retinaldehyde (RAL) treatments on skin, using different concentrations of retinal (0.05% and 0.1%).

Materials and methods: Employing a split-face design and noninvasive methods such as high-frequency ultrasonography, the Antera 3D camera, and the Cutometer, the effectiveness of these preparations was assessed among 56 women aged 30-58 years.

Results: The application of topical stabilized RAL resulted in statistically significant improvements in skin parameters. High-frequency ultrasonography revealed increased dermal density across all facial regions after 24 weeks, while Cutometer measurements showed enhanced skin elasticity and viscoelasticity. Antera 3D imaging demonstrated significant reductions in wrinkle parameters, particularly with the higher concentration (0.1%) of RAL. The treatments were generally well-tolerated, with minimal adverse effects reported, highlighting their suitability for sensitive skin.

Conclusion: Results indicated significant improvements in skin texture and firmness, particularly with the higher 0.1% concentration of RAL over 24-week period, making it a promising option for long-term skin rejuvenation therapy.

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局部稳定视黄醛0.1%与0.05%对皮肤生物物理和生物力学参数的比较评价。

背景：本研究的目的是评价不同浓度（0.05%和0.1%）的视网膜局部稳定视黄醛（RAL）对皮肤的生物物理和生物力学影响。材料和方法：采用裂面设计和非侵入性方法，如高频超声、Antera 3D相机和Cutometer，对56名30-58岁的女性进行了这些制剂的有效性评估。结果：外用稳定型RAL可显著改善皮肤参数。24周后，高频超声检查显示面部所有区域的真皮密度增加，而自动测量仪显示皮肤弹性和粘弹性增强。Antera 3D成像显示皱纹参数显着降低，特别是当RAL浓度较高（0.1%）时。这些治疗通常耐受性良好，副作用最小，突出了它们对敏感皮肤的适用性。结论：结果显示皮肤质地和紧致度有显著改善，特别是在24周的时间内，0.1%的RAL浓度较高，使其成为长期皮肤年轻化治疗的有希望的选择。

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来源期刊

Skin Research and Technology 医学-皮肤病学

CiteScore

3.30

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.