Real-World Performance of Aspergillus and Mucorales Polymerase Chain Reaction Assays on Bronchoalveolar Lavage Fluid in Immunocompromised Children and Young Adults.

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Journal of the Pediatric Infectious Diseases Society Pub Date : 2026-03-20 DOI:10.1093/jpids/piag012

Caitlin Brammer, Daniel Whitehurst, Hilary Miller-Handley, Grant Paulsen, Lara Danziger-Isakov, William Otto

引用次数: 0

Abstract

We describe use of Aspergillus and Mucorales polymerase chain reaction (PCRs) in 54 immunocompromised children and young adults undergoing 66 bronchoscopies. Test positivity was 2/54 (3.2%) and 1/59 (1.7%) for Aspergillus and Mucorales. For Aspergillus PCRs, 4/54 (7.4%) positively impacted management, compared to 4/59 (6.8%) for Mucorales. Fungal PCRs may influence care of immunocompromised patients, though overall impact was limited.

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免疫功能低下儿童和青少年支气管肺泡灌洗液中曲霉和粘膜聚合酶链反应的实际表现

我们描述了在54名接受66次支气管镜检查的免疫功能低下的儿童和年轻人中使用曲霉和Mucorales pcr。曲霉和毛霉的检测阳性率分别为2/54（3.2%）和1/59（1.7%）。对于曲霉pcr， 4/54（7.4%）对管理产生积极影响，而对毛霉菌的影响为4/59（6.8%）。真菌pcr可能影响免疫功能低下患者的护理，但总体影响有限。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Pediatric Infectious Diseases Society Medicine-Pediatrics, Perinatology and Child Health

CiteScore

6.70

自引率

0.00%

发文量

179

期刊介绍： The Journal of the Pediatric Infectious Diseases Society (JPIDS), the official journal of the Pediatric Infectious Diseases Society, is dedicated to perinatal, childhood, and adolescent infectious diseases. The journal is a high-quality source of original research articles, clinical trial reports, guidelines, and topical reviews, with particular attention to the interests and needs of the global pediatric infectious diseases communities.