Vestibular dysfunction in people with diabetes is predicted by clinical measures of peripheral neuropathy and associated with imbalance and low physical activity

IF 4.6 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2026-03-01 Epub Date: 2026-02-15 DOI:10.1016/j.diabres.2026.113162

Frank E. DiLiberto , Heather E.R. Kamath , Maxine L. Olson , Steven A. Miller , Janet O. Helminski , Marcello Cherchi , Michael C. Schubert

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引用次数: 0

Abstract

Aims

To characterize and predict otolith dysfunction of the peripheral vestibular system and its effect on balance in people with diabetes mellitus (DM).

Methods

This cross-sectional study included people with DM and peripheral neuropathy (PN), DM without PN, and controls (N = 68). Participant characteristics (e.g., age, HbA1c) including clinical measures of PN were procured. Cervical (saccule pathway) and ocular (utricle pathway) vestibular evoked myogenic potential (VEMP) testing outcomes included interamplitude and absent response counts. The Functional Gait Assessment and activity watch step counts characterized participant function. VEMP outcomes were compared between groups. In all DM participants, logistic regression was used to predict VEMP responses from participant characteristics, and functional outcomes were compared between those with and without VEMP responses.

Results

Worse PN predicted abnormal utricle and saccule function (1.1 ≤ odds ratio ≤ 1.7, p ≤ 0.05). Utricle function was the worst (p ≤ 0.04) and more frequently absent in those with DMPN. Balance and physical activity were worse in those with absent utricle (p ≤ 0.03), but not saccule, responses.

Conclusions

Clinical measures of PN can provide rationale for vestibular testing as those with DM and abnormal utricle function have imbalance and low physical activity.

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糖尿病患者的前庭功能障碍可通过周围神经病变的临床测量来预测，并与失衡和低体力活动相关。

目的：探讨糖尿病患者周围前庭系统耳石功能障碍及其对平衡的影响。方法：本横断面研究包括DM合并周围神经病变（PN）、DM无PN和对照组（N = 68）。获取参与者的特征（如年龄、HbA1c），包括PN的临床测量。颈椎（球囊通路）和眼（小囊通路）前庭诱发肌电位（VEMP）检测结果包括振幅间和缺席反应计数。功能性步态评估和活动手表步数表征了参与者的功能。比较各组间VEMP结果。在所有糖尿病参与者中，根据参与者特征使用逻辑回归预测VEMP反应，并比较有和没有VEMP反应的功能结果。结果：较差的PN预示着胞室和囊功能异常（1.1 ≤ 优势比 ≤ 1.7,p ≤ 0.05）。DMPN患者的胞囊功能最差（p ≤ 0.04），且更常缺失。胞室缺失患者的平衡和体力活动较差（p ≤ 0.03），但囊性反应不明显。结论：糖尿病合并前庭神经功能异常的患者存在神经失衡和低体力活动，临床测量PN可为前庭神经功能检查提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.