Sjogren's syndrome-Case series and literature review.

Abstract

Sjogren's syndrome (SS) is a chronic autoimmune disorder characterised by lymphocytic infiltration of exocrine glands, leading to xerostomia and keratoconjunctivitis sicca. To analyse the demographic details, clinical presentations, and serological and histopathological findings in a series of patients diagnosed with SS. This retrospective case series of SS was conducted at a tertiary institution in Kerala. The study comprised 10 patients with a mean age of 49 years, exhibiting a female-to-male ratio of 9:1. The most common clinical signs included xerostomia (90%), xerophthalmia (100%). Histopathological examination revealed focal lymphocytic sialadenitis in all cases (100%), with a mean focus score of 1.35. SS predominantly affects middle-aged women and presents with sicca symptoms. Histopathological examination of labial salivary glands remains the valuable diagnostic tool. Future research should concentrate on exploring targeted therapies that can improve the quality of life for those affected by SS.