Chemopreventive Effects of Lycopene in miR-21 Knockout and Wild-Type Pancreatic Cancer Cells.

IF 2.3 Q2 BIOLOGY

Scientifica Pub Date : 2026-02-12 eCollection Date: 2026-01-01 DOI:10.1155/sci5/8865270

Basak Dalbayrak, Burcu Taluğ Taştan, Tuğçe Temel, Pinar Obakan Yerlikaya, Pinar Uysal Onganer, Elif Damla Arisan

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Abstract

Pancreatic cancer is one of the most lethal malignancies, characterized by late diagnosis, rapid progression, and resistance to conventional therapies. The oncogenic microRNA miR-21 is frequently upregulated in pancreatic tumors and contributes to tumor growth, migration, and chemoresistance by targeting tumor suppressor genes. Lycopene, a naturally occurring carotenoid with antioxidant and anti-inflammatory properties, has shown promise as a chemopreventive agent in several cancer types. This study investigates the therapeutic potential of lycopene in human pancreatic cancer cell lines (PANC-1 and MIA PaCa-2) and their miR-21 knockout counterparts. Treatment with 50 μM lycopene significantly reduced cell viability, colony formation, migration, and spheroid integrity and decreased intracellular reactive oxygen species (ROS) levels, with more pronounced effects in miR-21-deficient cells. These findings highlight the role of miR-21 in modulating lycopene sensitivity and support the potential of lycopene as an adjunctive therapeutic agent in pancreatic cancer.

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番茄红素在miR-21敲除和野生型胰腺癌细胞中的化学预防作用

胰腺癌是最致命的恶性肿瘤之一，其特点是诊断晚、进展快、对常规治疗有耐药性。致癌microRNA miR-21在胰腺肿瘤中经常上调，并通过靶向肿瘤抑制基因参与肿瘤生长、迁移和化疗耐药。番茄红素是一种天然存在的类胡萝卜素，具有抗氧化和抗炎的特性，已经显示出作为几种癌症的化学预防剂的前景。本研究探讨了番茄红素在人胰腺癌细胞系（PANC-1和MIA PaCa-2）及其miR-21敲除对应物中的治疗潜力。用50 μM番茄红素处理可显著降低细胞活力、集落形成、迁移和球体完整性，并降低细胞内活性氧（ROS）水平，对mir -21缺陷细胞的影响更为明显。这些发现强调了miR-21在调节番茄红素敏感性中的作用，并支持了番茄红素作为胰腺癌辅助治疗剂的潜力。

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来源期刊

Scientifica BIOLOGY-

CiteScore

6.70

自引率

0.00%

发文量

审稿时长

21 weeks

期刊介绍： Scientifica is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies covering a wide range of subjects in the life sciences, environmental sciences, health sciences, and medicine. The journal is divided into the 65 subject areas.