{"title":"Dose-temperature interactions in gamma-irradiated tendon allografts: A multidimensional analysis.","authors":"Yanlin Wan, Dayong Liu, Xiaolong Wang, Limin Wang, Jingyu Zhang, Yongcheng Hu","doi":"10.1177/08853282261426964","DOIUrl":null,"url":null,"abstract":"<p><p>This study evaluated the impact of cryoprotection temperature on the structural and biomechanical properties of gamma-irradiated human tendon allografts. Tendons were irradiated at 15 kGy or 25 kGy under three temperature conditions: -70°C, 0°C, or room temperature (RT). Structural integrity was assessed histologically and biochemically, while biomechanical properties were measured via tensile testing. Tendons irradiated at RT exhibited severe collagen disorganization and cellular loss, whereas those cryoprotected at -70°C retained aligned collagen structure with minimal disruption. Biomechanically, the -70°C groups showed significantly higher maximum stress than RT groups at both irradiation doses. Increasing irradiation dose exacerbated structural and mechanical degradation, but these effects were substantially mitigated by cryoprotection at -70°C. Thus, low-temperature protection during gamma irradiation is crucial for preserving the integrity of tendon allografts.</p>","PeriodicalId":15138,"journal":{"name":"Journal of Biomaterials Applications","volume":" ","pages":"336-348"},"PeriodicalIF":2.4000,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomaterials Applications","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/08853282261426964","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/16 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
This study evaluated the impact of cryoprotection temperature on the structural and biomechanical properties of gamma-irradiated human tendon allografts. Tendons were irradiated at 15 kGy or 25 kGy under three temperature conditions: -70°C, 0°C, or room temperature (RT). Structural integrity was assessed histologically and biochemically, while biomechanical properties were measured via tensile testing. Tendons irradiated at RT exhibited severe collagen disorganization and cellular loss, whereas those cryoprotected at -70°C retained aligned collagen structure with minimal disruption. Biomechanically, the -70°C groups showed significantly higher maximum stress than RT groups at both irradiation doses. Increasing irradiation dose exacerbated structural and mechanical degradation, but these effects were substantially mitigated by cryoprotection at -70°C. Thus, low-temperature protection during gamma irradiation is crucial for preserving the integrity of tendon allografts.
期刊介绍：
The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials.
Peer-reviewed articles by biomedical specialists from around the world cover:
New developments in biomaterials, R&D, properties and performance, evaluation and applications
Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices
Current findings in biological compatibility/incompatibility of biomaterials
The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use.
The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.
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