{"title":"Autophagy and stress tolerance in plants: the central role of ATG18-a review.","authors":"Sishan Wei, Zexun Chen, Chenkai Xu, Xin Qian, Qiong Tang","doi":"10.1080/07388551.2026.2621917","DOIUrl":null,"url":null,"abstract":"<p><p>Autophagy is an ancient, conserved system that underpins plant survival by recycling damaged organelles and nutrients under biotic and abiotic stress. This review synthesizes recent advances in three autophagic pathways in plants and the core ATG machinery that executes them. Among them, ATG18, functioning as a phosphatidylinositol 3-phosphate (PI3P) effector, is indispensable for plant survival under stress, underscoring its critical significance. By integrating biotic/abiotic signals <i>via</i> post-translational modifications, it dynamically regulates autophagy to clear damaged components, recycle nutrients, and enhance disease resistance. It provides a theoretical framework for elucidating plant resistance and suggests strategies such as promoter editing, allele pyramiding, and CRISPR-mediated expression tuning to exploit ATG18 for breeding crops with combined disease resistance and abiotic-stress tolerance, offering valuable perspectives for agricultural advancement.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"562-581"},"PeriodicalIF":8.7000,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/07388551.2026.2621917","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/15 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Autophagy is an ancient, conserved system that underpins plant survival by recycling damaged organelles and nutrients under biotic and abiotic stress. This review synthesizes recent advances in three autophagic pathways in plants and the core ATG machinery that executes them. Among them, ATG18, functioning as a phosphatidylinositol 3-phosphate (PI3P) effector, is indispensable for plant survival under stress, underscoring its critical significance. By integrating biotic/abiotic signals via post-translational modifications, it dynamically regulates autophagy to clear damaged components, recycle nutrients, and enhance disease resistance. It provides a theoretical framework for elucidating plant resistance and suggests strategies such as promoter editing, allele pyramiding, and CRISPR-mediated expression tuning to exploit ATG18 for breeding crops with combined disease resistance and abiotic-stress tolerance, offering valuable perspectives for agricultural advancement.
期刊介绍：
Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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