Polyethylene Carboxylates Synthesized via Statistical Optimization: A Biocompatible Polymer Scaffold for Bioactive Conjugation

IF 2.5 4区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biotechnology and applied biochemistry Pub Date : 2026-08-06 Epub Date: 2026-02-15 DOI:10.1002/bab.70142

Vinay Sagar Verma, Rajesh Choudhary, Amit Alexander, Ajit Kumar Pandey, Aakansha Pandey, Hemant Ramchandra Badwaik, Ajazuddin

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引用次数: 0

Abstract

The study aimed to synthesize and evaluate polyethylene carboxylates (PECs) as a biocompatible polymer for drug delivery. The synthesis of PECs has been achieved by making slight modifications through statistical optimization in reaction conditions using the Jones reagent. The transformation has been confirmed by FTIR, NMR, and mass spectroscopy. The synthesized polymer was evaluated for its acute toxicity and ulcerogenic and hemolytic activity. The results revealed that PECs have successfully synthesized and have not shown any toxicity-related mortality. Moreover, PECs did not show any ulcerogenic and hemolytic activity, which was expected due to the presence of two carboxylic groups in the synthesized derivatives. The ease of performing the reaction and mild reagents make it the most suitable condition for synthesizing PECs. Biocompatibility (safety issues) regarding the employability of synthesized PECs has been tested, and the results have supported the same. The availability of the carboxylic group will open possibilities for the conjugation of bioactive compounds. This research work widens the scope for conjugation of most of the bioactive compounds and also proves to be an option for the linkers as they, by themselves, can be directly involved in the formation of polymer–drug conjugates.

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统计优化合成的聚羧酸酯：用于生物活性偶联的生物相容性聚合物支架。

本研究旨在合成并评价聚羧酸酯（PECs）作为一种生物相容性的给药聚合物。利用Jones试剂对反应条件进行了统计优化，从而实现了PECs的合成。该转变已被FTIR、NMR和质谱所证实。对合成的聚合物进行了急性毒性、溃疡和溶血活性评价。结果显示，PECs已成功合成，并没有显示出任何毒性相关的死亡率。此外，PECs没有表现出任何溃疡和溶血活性，这是预期的，因为在合成的衍生物中存在两个羧基。该反应容易进行，试剂温和，是合成PECs的最适宜条件。已对合成PECs的就业能力进行了生物相容性（安全问题）测试，结果也支持这一观点。羧基的可用性将为生物活性化合物的偶联提供可能性。这项研究工作拓宽了大多数生物活性化合物缀合的范围，也证明了连接物的一种选择，因为它们本身可以直接参与聚合物-药物缀合物的形成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biotechnology and applied biochemistry 工程技术-生化与分子生物学

CiteScore

6.00

自引率

7.10%

发文量

117

审稿时长

3 months

期刊介绍： Published since 1979, Biotechnology and Applied Biochemistry is dedicated to the rapid publication of high quality, significant research at the interface between life sciences and their technological exploitation. The Editors will consider papers for publication based on their novelty and impact as well as their contribution to the advancement of medical biotechnology and industrial biotechnology, covering cutting-edge research in synthetic biology, systems biology, metabolic engineering, bioengineering, biomaterials, biosensing, and nano-biotechnology.