Prevention of Pain on Propofol Injection: A Comparison of Pretreatment with 5-Hydroxytryptamine 3 Antagonists Granisetron, Ondansetron, and Ramosetron.

IF 1 Q3 MEDICINE, GENERAL & INTERNAL

Annals of African Medicine Pub Date : 2026-11-01 Epub Date: 2026-02-16 DOI:10.4103/aam.aam_360_25

Srishti Kindo, Nitesh Sinha, Dipali Singh, Subodh Kumar, Shio Priye, Khushboo Saran, Jay Prakash

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Abstract

Background and aims: Propofol is commonly used for the induction and maintenance of anesthesia. However, approximately 28%-90% of patients experience pain during injection. In this study, we compared the effectiveness of ondansetron, ramosetron, and granisetron, the three common 5-hydroxytryptamine 3 receptor antagonists in reducing the incidence and severity of propofol-induced pain (PIP).

Methods: This study included 120 adult patients (18-65 years old) scheduled for elective laparoscopic cholecystectomy under general anesthesia. Patients were randomly assigned to four groups ( n = 30 for each group). Granisetron (2 mg) was administered to Group G, ramosetron (0.3 mg) to Group R, ondansetron (4 mg) to Group O, and normal saline to Group N. Venous circulation was occluded by a rubber tourniquet to retain the drug in the vein and prevent its spread in circulation. Pain was assessed at 0, 5, 10, 15, and 20 s using a four-point verbal rating scale (VRS). The Kruskal-Wallis, Chi-square, Friedman tests, and generalized estimating equations were used to analyze the data.

Results: Groups O, R, and G demonstrated significantly reduced pain compared to group N at all-time points ( P < 0.001). Granisetron (Group G) was the most effective, with a mean VRS of 0.00 at 20 s. PIP incidence was 100% in Group N, compared to 80%, 70%, and 26.7% in Groups O, R, and G, respectively (χ² =40.443, P < 0.001).

Conclusion: Granisetron is the most effective in reducing PIP, though ondansetron and ramosetron also offer significant pain relief.

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异丙酚注射预防疼痛：5-羟色胺3拮抗剂格拉司琼、昂丹司琼和雷莫司琼预处理的比较。

背景和目的：异丙酚常用于麻醉诱导和维持。然而，大约28%-90%的患者在注射时感到疼痛。在这项研究中，我们比较了昂丹司琼、雷莫司琼和格拉司琼这三种常见的5-羟色胺3受体拮抗剂在降低异丙酚引起的疼痛（PIP）发生率和严重程度方面的有效性。方法：本研究纳入120例在全麻下行择期腹腔镜胆囊切除术的成年患者（18-65岁）。患者随机分为4组，每组30例。G组给予格拉司琼（2 mg）， R组给予雷莫司琼（0.3 mg）， O组给予昂丹司琼（4 mg）， n组给予生理盐水。用橡胶止血带阻断静脉循环，使药物保持在静脉中，防止药物在循环中扩散。采用四分口头评定量表（VRS）对疼痛进行0、5、10、15和20分的评估。采用Kruskal-Wallis检验、卡方检验、Friedman检验和广义估计方程对数据进行分析。结果：与N组相比，0组、R组和G组在所有时间点的疼痛均显著减轻（P < 0.001）。格拉司琼（G组）最有效，20 s时平均VRS为0.00。N组PIP发生率为100%，O、R、G组分别为80%、70%、26.7% （χ 2 =40.443, P < 0.001）。结论：格拉司琼对降低PIP最有效，但昂丹司琼和雷莫司琼也有显著的镇痛作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of African Medicine MEDICINE, GENERAL & INTERNAL-

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0.90

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0.00%

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期刊介绍： The Annals of African Medicine is published by the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the Annals of African Medicine Society. The Journal is intended to serve as a medium for the publication of research findings in the broad field of Medicine in Africa and other developing countries, and elsewhere which have relevance to Africa. It will serve as a source of information on the state of the art of Medicine in Africa, for continuing education for doctors in Africa and other developing countries, and also for the publication of meetings and conferences. The journal will publish articles I any field of Medicine and other fields which have relevance or implications for Medicine.