Clinico-Morphological and Genetic Features of Colorectal Cancer in Multiple Primary Cancers Cases.

IF 1.9 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Genetics Pub Date : 2026-08-01 Epub Date: 2026-02-16 DOI:10.1007/s10528-026-11328-y

Natalya N Timoshkina, Dmitry Yu Gvaldin, Dema Alset, Inna A Novikova, Oleg I Kit

引用次数: 0

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结直肠癌多原发病例的临床形态学和遗传学特征。

结直肠癌（CRC）是一种高发病率的恶性肿瘤，可以作为多原发癌症（MPCs）的一部分被发现。虽然MPCs的分子机制已被广泛讨论，但尚未完全了解。本研究的目的是调查俄罗斯队列患者中MPCs结直肠成分的临床和遗传特征。纳入512例结直肠癌患者（62例同步和/或异时性MPCs）。从石蜡包埋组织中分离DNA，分析KRAS、NRAS、BRAF突变和MSI状态，并进行靶向高通量测序。使用生物信息学工具对结果进行分析，以检测不同的遗传变化。在性别、年龄和组织学类型方面，MPCs和单一CRC （sCRC）之间没有显著差异。粘液腺癌在45岁以下的MPCs患者中更常见，但在老年sCRC患者中更常见。横结肠肿瘤在MPCs中显著增加（p = 0.004），直肠恶性肿瘤主要在sCRC中记录（p = 0.005）。与sCRC组相比，MPCs组KRAS （G12A）和MSI-H的频率显著升高(p

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来源期刊

Biochemical Genetics 生物-生化与分子生物学

CiteScore

3.90

自引率

0.00%

发文量

133

审稿时长

4.8 months

期刊介绍： Biochemical Genetics welcomes original manuscripts that address and test clear scientific hypotheses, are directed to a broad scientific audience, and clearly contribute to the advancement of the field through the use of sound sampling or experimental design, reliable analytical methodologies and robust statistical analyses. Although studies focusing on particular regions and target organisms are welcome, it is not the journal’s goal to publish essentially descriptive studies that provide results with narrow applicability, or are based on very small samples or pseudoreplication. Rather, Biochemical Genetics welcomes review articles that go beyond summarizing previous publications and create added value through the systematic analysis and critique of the current state of knowledge or by conducting meta-analyses. Methodological articles are also within the scope of Biological Genetics, particularly when new laboratory techniques or computational approaches are fully described and thoroughly compared with the existing benchmark methods. Biochemical Genetics welcomes articles on the following topics: Genomics; Proteomics; Population genetics; Phylogenetics; Metagenomics; Microbial genetics; Genetics and evolution of wild and cultivated plants; Animal genetics and evolution; Human genetics and evolution; Genetic disorders; Genetic markers of diseases; Gene technology and therapy; Experimental and analytical methods; Statistical and computational methods.