The association between single-nucleotide polymorphisms of FDPS Rs2297480 and MECP2 Rs2734647 genes and the susceptibility to rheumatoid arthritis in Egyptian patients.

Abstract

Background: Rheumatoid arthritis (RA) has a complex etiology that involves environmental and genetic variables. The identification of new genetic connections contributes to accelerating the development of customized medications to treat or delay the progression of diseases.

Objective: We aimed to assess the relationship between rheumatoid arthritis susceptibility and genetic variations of the Farnesyl Diphosphate Synthase (FDPS) and methyl CpG binding protein 2 (MECP2) genes.

Patients and methods: 100 patients with rheumatoid arthritis and 100 healthy control subjects participated in this case-control research. Genetic analyses for single-nucleotide polymorphisms (SNPs) in the FDPS and MeCP2 genes were performed on the patients.

Results: In terms of FDPS genetic polymorphisms, the sick group had greater frequencies of the TG and GG genotypes, whereas the control group had a higher frequency of the TT genotype. The CC genotype was more common in the control group, but the TC and TT genotypes were more common in the sick group concerning MECP2 genetic polymorphisms.

Conclusion: For rheumatoid arthritis, the FDPS (rs2297480) TT genotype seemed to be protective. An increased risk of rheumatoid arthritis was linked to the MECP2 (rs2734647) TT genotype, but the CC genotype seemed to be protective against the condition.