ASSOCIATIONS BETWEEN SLEEP DISORDERS AND AGE-RELATED MACULAR DEGENERATION: A Systematic Review and Meta-Analysis.

IF 2.1 2区医学 Q2 OPHTHALMOLOGY

Retina-The Journal of Retinal and Vitreous Diseases Pub Date : 2026-07-01 DOI:10.1097/IAE.0000000000004800

Lucas Macedo Nascimento, Ricardo Louzada, Dillan Cunha Amaral, Raíza Jacometti, Vitória Palazoni Viegas Mendonça, Benjamin Chamis, João Victor Pereira Gonzalez, Caio Toscano Lessa, Mário Luiz Ribeiro Monteiro, Daniela Ferrara

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引用次数: 0

Abstract

Purpose: To evaluate the relationship between sleep disorders, including insomnia and obstructive sleep apnea (OSA), personal chronotype, and age-related macular degeneration (AMD).

Methods: The authors systematically reviewed articles in PubMed, EMBASE, and Web of Science that provided information on AMD and sleep disorders, whether qualitative or quantitative. The authors systematically screened the abstracts of potentially eligible studies and subsequently assessed the full-text reports of those deemed relevant in detail. The study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Results: Twenty-two studies were included in their final review. Obstructive sleep apnea was associated with a higher risk of AMD, based on seven studies (hazard ratio 1.43; 95% confidence interval (CI) 1.14-1.79 P < 0.001; I 2 = 96%). The analysis showed a statistically significant association between the morning person chronotype and an increased odds of AMD (OR 1.19; 95% CI 1.10-1.30; P < 0.001; I 2 = 0%). The authors found little to no association between sleep duration (SD) and insomnia.

Conclusion: Their meta-analyses, although based on a limited number of studies, indicate that sleep disorders, particularly OSA, are associated with increased odds of developing AMD. However, further research is needed to understand how SD affects disease progression and to determine the benefits of treating sleep disorders for AMD.

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睡眠障碍与年龄相关性黄斑变性之间的关系：一项系统综述和荟萃分析。

目的：评估睡眠障碍（包括失眠和阻塞性睡眠呼吸暂停（OSA））、个人睡眠类型和年龄相关性黄斑变性（AMD）之间的关系。方法：我们系统地回顾了PubMed、EMBASE和Web of Science中提供AMD和睡眠障碍相关信息的文章，无论是定性的还是定量的。我们系统地筛选了可能符合条件的研究摘要，随后详细评估了那些被认为相关的全文报告。该研究遵循了系统评价和荟萃分析的首选报告项目（PRISMA）指南。结果：我们的最终综述纳入了22项研究。根据7项研究，OSA与AMD的高风险相关（HR 1.43; 95% CI 1.14-1.79 p < 0.001; I2 = 96%）。分析显示，早起的人的生物钟类型与AMD发病率增加之间存在统计学上显著的关联（OR 1.19; 95% CI 1.10-1.30; p < 0.001; I2 = 0%）。我们发现睡眠时长和失眠之间几乎没有联系。结论：我们的荟萃分析虽然基于有限数量的研究，但表明睡眠障碍，特别是OSA，与AMD发病几率增加有关。然而，需要进一步的研究来了解睡眠时间如何影响疾病进展，并确定治疗AMD睡眠障碍的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retina-The Journal of Retinal and Vitreous Diseases 医学-眼科学

CiteScore

5.70

自引率

9.10%

发文量

554

审稿时长

3-6 weeks

期刊介绍： RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice. In addition to regular reports from clinical and basic science investigators, RETINA® publishes special features including periodic review articles on pertinent topics, special articles dealing with surgical and other therapeutic techniques, and abstract cards. Issues are abundantly illustrated in vivid full color. Published 12 times per year, RETINA® is truly a “must have” publication for anyone connected to this field.