Susceptibility mapping of deep gray matter in Wilson’s disease: A systematic review and meta-analysis

IF 3.4 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2026-04-01 Epub Date: 2026-02-12 DOI:10.1016/j.parkreldis.2026.108235

Laís Silva Santana , Guilherme José da Costa Borsatto , Marianna Leite , Maressa Mouty Rabello , Eberval Gadelha Figueiredo , João Paulo Mota Telles

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引用次数: 0

Abstract

Quantitative susceptibility mapping (QSM) enables assessment of brain metal deposition. This meta-analysis evaluated QSM alterations in Wilson's disease (WD). PubMed, Embase, and Web of Science were searched up to September 2025 for studies reporting QSM measurements in neurological or hepatic WD and healthy controls (HCs). Twelve studies were included (325 WD, 254 HCs). Neurological WD showed higher susceptibility than HCs in the caudate (mean difference [MD] = 33.92, 95% CI: 18.14–49.70, p < .001), putamen (MD = 48.42, 95% CI: 29.66–67.17, p < .001), globus pallidus (MD = 62.24, 95% CI: 39.74–84.73, p < .001), thalamus (MD = 15.15, 95% CI: 10.15–20.15, p < .001), red nucleus (MD = 30.25, 95% CI: 12.57–47.93, p < .001), and dentate nucleus (MD = 16.65, 95% CI: 2.52–30.78, p = .02). Compared with hepatic-onset WD, neurological presentations showed higher susceptibility in the caudate nucleus (MD = 23.45, 95% CI: 1.17–45.73, p = .04), putamen (MD = 43.20, 95% CI: 2.62–83.78, p = .04), and thalamus (MD = 11.11, 95% CI: 7.53–14.69, p < .001). Hepatic-onset WD showed milder increases versus HCs in the globus pallidus (MD = 18.13, 95% CI: 4.42–31.85, p = .01), red nucleus (MD = 16.87, 95% CI: 12.11–21.63, p < .001) and dentate nucleus (MD = 11.61, 95% CI: 8.28–14.95, p < .001). QSM reveals marked susceptibility elevations in neurological WD and mild changes in hepatic WD.

Trial registration

CRD420251232999, https://www.crd.york.ac.uk/PROSPERO/view/CRD420251232999.

查看原文本刊更多论文

威尔逊病中深灰质的易感性图谱：系统回顾和荟萃分析。

定量敏感性制图（QSM）可以评估脑金属沉积。本荟萃分析评估了威尔逊氏病（WD）的QSM改变。PubMed、Embase和Web of Science检索了截至2025年9月报道神经或肝脏WD和健康对照（hc） QSM测量的研究。纳入了12项研究（325例WD， 254例hc）。神经性WD的易感性高于尾状核hc(平均差异[MD] = 33.92, 95% CI: 18.14 ~ 49.70, p

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.