GNRs/Ti3C2 MXene improved optical fiber LSPR acetylcholine biosensors

IF 2.7 3区计算机科学 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Optical Fiber Technology Pub Date : 2026-07-01 Epub Date: 2026-02-03 DOI:10.1016/j.yofte.2026.104563

Yumei Zhang , Baoquan Xiao , Zelin Gao , Li Yang , Dekui Zhang , Ning Wang , Tuanjie Che , Xusheng Xia , Liyun Ding

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引用次数: 0

Abstract

The rapid, accurate and highly sensitive detection of acetylcholine, which was one of the neurotransmitters related to a variety of neurodegenerative diseases has great significance for disease screening, treatment and prognosis. This paper proposed a GNRs/Ti₃C₂ MXene enhanced optical fiber LSPR acetylcholine biosensor by depositing Ti₃C₂ MXene nanosheets on the surface of a GNRs-based optical fiber sensing probe via simple electrostatic self-assembly. The refractive index sensitivity of the biosensor was improved due to the advantages of the large specific surface area, hydrophilicity and broadband absorption spectrum of 2D Ti₃C₂ MXene nanosheets. The refractive index sensitivity of the biosensor with Ti₃C₂ MXene nanosheets was improved by 44 % compared to that of the GNRs-based biosensor. The biosensor had a good linear relationship in the range of 0–900 μM for acetylcholine concentration with a sensitivity of 0.0304 nm/μM and the detection limit was 6.58 μM. The results indicated that the proposed GNRs/Ti₃C₂ MXene enhanced optical fiber LSPR acetylcholine biosensor provides a promising avenue of detection for in biotechnology and medicine files.

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GNRs/Ti3C2 MXene改进光纤LSPR乙酰胆碱生物传感器

乙酰胆碱是多种神经退行性疾病相关的神经递质之一，其快速、准确、高灵敏度的检测对疾病的筛查、治疗和预后具有重要意义。通过简单的静电自组装，在GNRs型光纤传感探头表面沉积Ti3C2 MXene纳米片，提出了一种GNRs/Ti3C2 MXene增强型光纤LSPR乙酰胆碱生物传感器。二维ti3c2mxene纳米片具有比表面积大、亲水性好、吸收光谱宽等优点，提高了生物传感器的折射率灵敏度。与基于gnrs的生物传感器相比，Ti3C2 MXene纳米片生物传感器的折射率灵敏度提高了44%。该传感器对乙酰胆碱浓度在0 ~ 900 μM范围内具有良好的线性关系，灵敏度为0.0304 nm/μM，检出限为6.58 μM。结果表明，本文提出的GNRs/Ti3C2 MXene增强光纤LSPR乙酰胆碱生物传感器在生物技术和医学领域具有广阔的应用前景。

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来源期刊

Optical Fiber Technology 工程技术-电信学

CiteScore

4.80

自引率

11.10%

发文量

327

审稿时长

63 days

期刊介绍： Innovations in optical fiber technology are revolutionizing world communications. Newly developed fiber amplifiers allow for direct transmission of high-speed signals over transcontinental distances without the need for electronic regeneration. Optical fibers find new applications in data processing. The impact of fiber materials, devices, and systems on communications in the coming decades will create an abundance of primary literature and the need for up-to-date reviews. Optical Fiber Technology: Materials, Devices, and Systems is a new cutting-edge journal designed to fill a need in this rapidly evolving field for speedy publication of regular length papers. Both theoretical and experimental papers on fiber materials, devices, and system performance evaluation and measurements are eligible, with emphasis on practical applications.