Synthesis of 2,3-Naphthalocyanine/ nickel hydroxide (2,3-Nc/Ni(OH)2) nanocomposite for uric acid electrochemical sensing

IF 3.7

Next Nanotechnology Pub Date : 2026-06-01 Epub Date: 2026-02-03 DOI:10.1016/j.nxnano.2026.100377

Omolola E. Fayemi , Saheed E. Elugoke , Funmilola Adesanya

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Abstract

The sensitive and selective detection of uric acid (UA) is crucial for the early diagnosis of several neurological diseases/disorders in the human body. In this study, nickel hydroxide (Ni(OH)₂ nanoparticles were synthesized using a wet chemical method and doped with 2,3-Naphthalocyanine (2,3-Nc) to form 2,3-Nc/Ni(OH)₂ nanocomposite for the detection of UA. The morphologies of the synthesized nanomaterials were investigated using transmission electron microscopy (TEM) and scanning electron microscopy (SEM) equipped with energy-dispersive X-ray spectroscopy (EDS), confirming the successful formation of the nanostructures. UV–visible spectroscopy (UV) was used to ascertain the optical characteristics of the nanocomposite. Fourier transform infrared spectroscopy (FTIR) identified the functional groups present, while X-ray diffraction (XRD) analyses validated the crystallinity of the synthesized nanomaterials. The UA sensors were fabricated by depositing Ni(OH)₂, 2,3-Nc, and 2,3-Nc/Ni(OH)₂ nanocomposite onto the screen-printed gold electrode (SPAuE). Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and square wave voltammetry (SWV) were used to evaluate the UA electrochemical sensing performance of the bare SPAuE, SPAuE/2,3-Nc, SPAuE/Ni(OH)₂, and SPAuE/2,3-Nc/Ni(OH)₂ electrodes. Using SWV, the SPAuE/2,3-Nc/Ni(OH)₂ electrode achieved a low limit of detection (LOD) of 14.16 μM with a linear range of 7.65 μM to 513.67 μM. The sensor’s selectivity and stability were also assessed. The applicability of the UA sensor was tested in spinach and baked beans samples through standard addition and recovery of known UA concentration. The high sensitivity of the porous 2,3-Nc/Ni(OH)₂ nanocomposite highlights its potential for the sensing of other biomolecules.

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2,3-萘菁/氢氧化镍（2,3- nc /Ni(OH)2）纳米复合材料尿酸电化学传感的合成

尿酸（UA）的敏感和选择性检测对人体几种神经系统疾病的早期诊断至关重要。本研究采用湿化学方法合成氢氧化镍(Ni(OH)2纳米粒子，并掺杂2,3-萘菁（2,3- nc），形成2,3- nc /Ni(OH)2纳米复合材料，用于检测UA。利用透射电子显微镜（TEM）和扫描电子显微镜（SEM）以及能量色散x射线能谱仪（EDS）对合成的纳米材料进行了形貌研究，证实了纳米结构的成功形成。紫外可见光谱（UV）测定了纳米复合材料的光学特性。傅里叶变换红外光谱（FTIR）鉴定了存在的官能团，x射线衍射（XRD）分析验证了合成纳米材料的结晶度。通过在丝网印刷金电极（SPAuE）上沉积Ni(OH) 2,2,3 - nc和2,3- nc /Ni(OH)2纳米复合材料制备UA传感器。采用循环伏安法（CV）、电化学阻抗谱法（EIS）和方波伏安法（SWV）对SPAuE裸电极、SPAuE/2,3- nc、SPAuE/Ni(OH)2和SPAuE/2,3- nc /Ni(OH)2的UA电化学传感性能进行了评价。采用SWV， SPAuE/2,3- nc /Ni(OH)2电极的检测下限为14.16 μM，线性范围为7.65 ~ 513.67 μM。对传感器的选择性和稳定性进行了评价。通过标准添加和回收已知UA浓度，测试了UA传感器在菠菜和烤豆样品中的适用性。多孔2,3- nc /Ni(OH)2纳米复合材料的高灵敏度突出了其对其他生物分子的传感潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Next Nanotechnology

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