Exploring rural-urban disparities in HPV vaccine initiation: new insights from the 2022 national health interview survey

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2026-03-19 Epub Date: 2026-02-10 DOI:10.1016/j.vaccine.2026.128334

Jason Semprini , Heather Brandt

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Abstract

As human papillomavirus (HPV)-associated cancers continue rising in rural America, identifying contributors to rural-urban gaps in HPV vaccination could inform public health priorities and targeted interventions. Analyzing nationally representative data from the 2022 National Health Interview Survey (NHIS), we evaluated rural-urban differences in HPV vaccination among individuals aged 9–29 years (all of whom were recommended to receive the HPV vaccine during adolescence since 2006). Generalized structural equation models adjusted for complex survey design, sociodemographic factors, and other vaccine utilization. Even after adjusting for other vaccine utilization, rural participants were 5.4%-points (CI = −9.7, −1.0) less likely to receive the HPV vaccine than urban participants. Rural-urban disparities in HPV vaccination varied by healthcare access barriers and geography, with the largest gap found in participants who were privately insured. Our work suggests that rural-urban disparities in HPV vaccination are driven by factors distinct from those associated with other vaccines and healthcare access.

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探索HPV疫苗接种的城乡差异：来自2022年全国健康访谈调查的新见解。

随着人类乳头瘤病毒（HPV）相关癌症在美国农村地区的持续上升，确定城乡HPV疫苗接种差距的原因可以为公共卫生优先事项和有针对性的干预提供信息。分析2022年全国健康访谈调查（NHIS）的全国代表性数据，我们评估了9-29岁人群（自2006年以来所有人都被建议在青春期接种HPV疫苗）中HPV疫苗接种的城乡差异。广义结构方程模型调整复杂的调查设计，社会人口因素，和其他疫苗的使用。即使在调整了其他疫苗的使用后，农村参与者接受HPV疫苗的可能性也比城市参与者低5.4% （CI = -9.7, -1.0）。城乡HPV疫苗接种的差异因医疗保健准入障碍和地理位置而异，其中私人保险参与者的差距最大。我们的工作表明，城乡HPV疫苗接种的差异是由与其他疫苗和医疗保健获取相关的因素不同的因素驱动的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

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