The prognostic value of perioperative neutrophil-lymphocyte ratio (NLR) as a predictor of outcomes after pediatric cardiac surgery: A systematic review and meta-analysis.

IF 0.5 4区医学 Q4 SURGERY

Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery Pub Date : 2026-04-06 Epub Date: 2026-02-12 DOI:10.4274/tjtcs.2025.28680

Fegita Beatrix Pajala, Sylvia Alicia Salim, Raden Haryo Aribowo

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引用次数: 0

Abstract

Background: The neutrophil-lymphocyte ratio (NLR) has been suggested as a valuable indicator of poor outcomes in patients undergoing cardiac surgery. However, its prognostic role in pediatric patients undergoing open-heart surgery is unclear. This study aimed to evaluate the correlation between the perioperative NLR and clinical outcomes after pediatric open-heart surgery under cardiopulmonary bypass (CPB).

Methods: A literature search was conducted from their inception to July 19, 2024 in PubMed Central, ProQuest, Sage, ScienceDirect and Ovid. We included studies that investigated the perioperative value of NLR as a predictor of outcomes after pediatric cardiac surgery under CPB. A meta-analysis was performed according to preferred reporting items for systematic reviews and meta-analyses guidelines. The Newcastle-Ottawa scale was used to assess the study quality, while JAMOVI statistical software was used to perform the meta-analysis.

Results: A total of six studies were included based on our eligibility criteria; however, only four were included for meta-analysis. The results showed a significant correlation between postoperative NLR with hospital (r=0.34 [95% confidence interval [CI] 0.10-0.58]) and intensive care unit (r=0.25 [95% CI 0.04-0.46]) length of stay.

Conclusion: NLR has shown potential as a simple and affordable inflammatory marker in pediatric cardiac surgery under CPB. However, its moderate to weak correlation with clinical outcomes necessitates cautious interpretation. Further research in the form of impact studies is warranted to strengthen these findings.

查看原文本刊更多论文

围手术期中性粒细胞-淋巴细胞比率（NLR）作为儿科心脏手术预后预测因子的预后价值：一项系统综述和荟萃分析。

背景：中性粒细胞-淋巴细胞比率（NLR）被认为是心脏手术患者预后不良的一个有价值的指标。然而，其在接受心脏直视手术的儿科患者中的预后作用尚不清楚。本研究旨在评估小儿体外循环直视手术（CPB）围手术期NLR与临床结果的相关性。方法：在PubMed Central、ProQuest、Sage、ScienceDirect和Ovid中检索自成立至2024年7月19日的文献。我们纳入了研究NLR作为CPB下儿童心脏手术预后预测因子的围手术期价值的研究。根据系统评价和meta分析指南的首选报告项目进行meta分析。采用Newcastle-Ottawa量表评估研究质量，采用JAMOVI统计软件进行meta分析。结果：根据我们的入选标准，共纳入6项研究；然而，只有4人被纳入meta分析。结果显示，术后NLR与住院时间（r=0.34[95%可信区间[CI] 0.10-0.58]）和重症监护病房（r=0.25 [95% CI 0.04-0.46]）有显著相关。结论：在CPB下的小儿心脏手术中，NLR已显示出作为一种简单且负担得起的炎症标志物的潜力。然而，其与临床结果的中度至弱相关性需要谨慎解释。有必要以影响研究的形式进行进一步研究，以加强这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery SURGERY-

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： The Turkish Journal of Thoracic and Cardiovascular Surgery is an international open access journal which publishes original articles on topics in generality of Cardiac, Thoracic, Arterial, Venous, Lymphatic Disorders and their managements. These encompass all relevant clinical, surgical and experimental studies, editorials, current and collective reviews, technical know-how papers, case reports, interesting images, How to Do It papers, correspondences, and commentaries.