The role of immunoproteasome in diabetes and diabetes-related complications

IF 9.4 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Genes & Diseases Pub Date : 2026-05-01 Epub Date: 2025-09-20 DOI:10.1016/j.gendis.2025.101861

Mengwen Wang , Lingyun Luo , Lei Dai , Hesong Zeng , Hongjie Wang

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Abstract

The immunoproteasome represents a specialized isoform of the proteasome that is integral to the processes of antigen presentation and protein degradation. While it is primarily expressed in hematopoietic cells, its expression can also be induced in non-hematopoietic cells in response to various inflammatory stimuli. Recent research has highlighted the role of the immunoproteasome in modulating islet β-cell apoptosis and glycolipid metabolism, both of which are critical mechanisms in the pathogenesis of diabetes. Furthermore, the immunoproteasome has been demonstrated to play a significant role in the development of diabetic complications through the activation of various downstream cytokines. Investigating how the immunoproteasome is activated and involved in the pathophysiological processes of diabetes and its complications may provide innovative and promising approaches for diabetes treatment. This review aims to present a comprehensive summary of current research on the role of immunoproteasome in diabetes and its associated complications, ultimately identifying novel strategies for diabetes management and therapy.

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免疫蛋白酶体在糖尿病及其相关并发症中的作用。

免疫蛋白酶体是蛋白酶体的一种特殊异构体，在抗原呈递和蛋白质降解过程中起着不可或缺的作用。虽然它主要在造血细胞中表达，但在各种炎症刺激下，它也可以在非造血细胞中被诱导表达。最近的研究强调了免疫蛋白酶体在调节胰岛β细胞凋亡和糖脂代谢中的作用，这两者都是糖尿病发病的关键机制。此外，免疫蛋白酶体已被证明通过激活各种下游细胞因子在糖尿病并发症的发展中发挥重要作用。研究免疫蛋白酶体如何被激活并参与糖尿病及其并发症的病理生理过程可能为糖尿病治疗提供创新和有前途的方法。本综述旨在全面总结免疫蛋白酶体在糖尿病及其相关并发症中的作用，最终确定糖尿病管理和治疗的新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genes & Diseases Multiple-

CiteScore

7.30

自引率

0.00%

发文量

347

审稿时长

49 days

期刊介绍： Genes & Diseases is an international journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human diseases. Publication formats include full length research article, review article, short communication, correspondence, perspectives, commentary, views on news, and research watch. Aims and Scopes Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies, and regenerative medicine.