Resilience factors and their role in clinical high-risk for psychosis

IF 3.7 2区医学 Q1 PSYCHIATRY

Schizophrenia Research Pub Date : 2026-04-01 Epub Date: 2026-02-10 DOI:10.1016/j.schres.2025.12.017

P. Do Lan , A.M. Isvoranu , B. Kleim , K. Heekeren , Rössler Wulf , A. Theodoridou

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引用次数: 0

Abstract

Objective

Recent approaches in psychosis research have emphasized the importance of the combined analysis of risk and resilience factors. A resilience-integrated approach offers a more comprehensive understanding of the mechanisms underlying symptom associations and progression in individuals at clinical high-risk (CHR) for psychosis. Network analysis allows the examination of relationships among mental health conditions together with both risk and resilience factors. To our knowledge, this is the first study that investigated associations between resilience, risk factors, and psychosis-risk using network analysis.

Methods

This secondary analysis of data from the ZInEP study (Zurich Early Recognition Program) examined 116 individuals at CHR for psychosis aged 18–35 years. We investigated the relationships between two candidate resilience factors (self-efficacy and self-esteem), daily hassles as a candidate risk factor, functioning level, and psychosis risk symptoms using network analysis.

Results

Self-esteem and self-efficacy were negatively associated with general symptoms, negative symptoms, and daily hassles. Resilience factors and daily hassles were not associated with positive and disorganized symptoms, nor with functioning level. Centrality analyses further revealed that self-esteem had stronger node strength and bridge strength than self-efficacy.

Conclusions

This study emphasizes the utility of a resilience-oriented approach in psychosis risk. Self-esteem and self-efficacy may play a crucial role in negative and general symptoms. Resilience factors may enrich our theoretical understanding of psychosis risk and help pave the way for resilience-based interventions.

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心理弹性因素及其在精神病临床高危人群中的作用。

目的：最近精神病研究的方法强调了风险因素和恢复因素的综合分析的重要性。一个复原力整合的方法提供了一个更全面的机制，潜在的症状关联和进展的个体在临床高危精神病（CHR）。网络分析允许检查心理健康状况与风险和恢复力因素之间的关系。据我们所知，这是第一个使用网络分析来调查弹性、风险因素和精神病风险之间关系的研究。方法：对ZInEP研究（苏黎世早期识别计划）的数据进行二次分析，在CHR检查了116名18-35岁的精神病患者。我们使用网络分析研究了两个候选弹性因素（自我效能感和自尊）、作为候选风险因素的日常纠纷、功能水平和精神病风险症状之间的关系。结果：自尊和自我效能感与一般症状、阴性症状和日常困扰呈负相关。恢复力因素和日常麻烦与阳性和紊乱症状无关，也与功能水平无关。中心性分析进一步发现自尊比自我效能具有更强的节点强度和桥梁强度。结论：本研究强调了心理弹性导向方法在精神病风险中的效用。自尊和自我效能感可能在消极和一般症状中起关键作用。弹性因素可以丰富我们对精神病风险的理论理解，并有助于为基于弹性的干预铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Schizophrenia Research 医学-精神病学

CiteScore

7.50

自引率

8.90%

发文量

429

审稿时长

10.2 weeks

期刊介绍： As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership! Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue. The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.