Seven undescribed metabolites from Ganoderma lucidum-derived endophytic Talaromyces sp. GLQ04 and their anti-DLBCL (diffuse large B-cell lymphoma) activities

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2026-06-01 Epub Date: 2026-02-09 DOI:10.1016/j.phytochem.2026.114816

Shan Liu , Hao Sun , Pei-Ting Li , Pei-Shan Li , Xia Cheng , Feng Wang , Qi Luo

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Abstract

Seven undescribed metabolites and four known compounds were isolated from a Ganoderma lucidum-derived endophytic fungus Talaromyces sp. GLQ04. Their structures including absolute configurations were assigned by using spectroscopic data and ECD calculations. Among them, (±)-3 and (±)-5 were obtained as a mixture. Chiral HPLC was employed to separate two pairs of enantiomers (+)-3 and (−)-3, and (+)-5 and (−)-5. The cytotoxic bioactivities of compounds 1–9 against DLBCL (diffuse large B-cell lymphoma) cells were evaluated. The results showed that compounds 6, 7 and 8 exhibited inhibitory activities against DLBCL cells, with IC₅₀ values of 10.68 μM, 61.04 μM and 17.12 μM, respectively.

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灵芝内生植物Talaromyces sp. GLQ04的7种未描述代谢物及其抗弥漫大b细胞淋巴瘤（dlbcl）活性。

从灵芝内生真菌Talaromyces sp. GLQ04中分离得到7个未描述的代谢物和4个已知化合物。通过光谱数据和ECD计算，确定了它们的结构，包括绝对构型。其中（±）-3和（±）-5为混合物。采用手性高效液相色谱法分离了两对对映体(+)-3和(-)-3,(+)-5和(-)-5。研究了化合物1-9对弥漫大b细胞淋巴瘤（DLBCL）细胞的细胞毒活性。结果表明，化合物6、7和8对DLBCL细胞具有抑制活性，IC50值分别为10.68 μM、61.04 μM和17.12 μM。

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.