{"title":"Effectiveness of Cranberry Supplementation for Prevention and Treatment of Infectious Urinary Tract Disease in Dogs and Cats: A Systematic Review","authors":"J. Scott Weese, Heather E. Weese","doi":"10.1111/jvp.70050","DOIUrl":null,"url":null,"abstract":"<p>Cranberry and cranberry extracts are available for treatment or prevention of urinary tract disease in dogs and cats, but guidance regarding their use is lacking. The objectives were to identify and assess literature pertaining to the efficacy of cranberry and cranberry extract supplementation for prevention and treatment of bacterial cystitis and subclinical bacteriuria in dogs and cats. A systematic review was performed, and three studies involving a total of 122 animals (106 dogs and 16 cats) were identified. No studies reported statistically significant or numerical impacts of treatment. Two studies were deemed at high risk of bias, and one was deemed at low risk. Certainty of evidence was low to very low. The small number of studies, small sample sizes, data from those studies, and low certainty of evidence preclude confident assessment of the role of cranberry for the prevention or treatment of infectious urinary tract disease in dogs and cats.</p>","PeriodicalId":17596,"journal":{"name":"Journal of veterinary pharmacology and therapeutics","volume":"49 2","pages":"102-109"},"PeriodicalIF":1.4000,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968518/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of veterinary pharmacology and therapeutics","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jvp.70050","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Cranberry and cranberry extracts are available for treatment or prevention of urinary tract disease in dogs and cats, but guidance regarding their use is lacking. The objectives were to identify and assess literature pertaining to the efficacy of cranberry and cranberry extract supplementation for prevention and treatment of bacterial cystitis and subclinical bacteriuria in dogs and cats. A systematic review was performed, and three studies involving a total of 122 animals (106 dogs and 16 cats) were identified. No studies reported statistically significant or numerical impacts of treatment. Two studies were deemed at high risk of bias, and one was deemed at low risk. Certainty of evidence was low to very low. The small number of studies, small sample sizes, data from those studies, and low certainty of evidence preclude confident assessment of the role of cranberry for the prevention or treatment of infectious urinary tract disease in dogs and cats.
期刊介绍：
The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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