Hydrostatic-pressure-dependent acoustic properties of brain tissue and their implications in non-invasive ICP monitoring

IF 2.9 3区医学 Q3 BIOPHYSICS

Journal of biomechanics Pub Date : 2026-03-01 Epub Date: 2026-02-06 DOI:10.1016/j.jbiomech.2026.113196

Junda Shen , Xiuwei Wan , Xingyu Yao , Yijia Shi , Yaohua Guo , Shujuan Lin , Jin Yang , Shaobao Liu

{"title":"Hydrostatic-pressure-dependent acoustic properties of brain tissue and their implications in non-invasive ICP monitoring","authors":"Junda Shen , Xiuwei Wan , Xingyu Yao , Yijia Shi , Yaohua Guo , Shujuan Lin , Jin Yang , Shaobao Liu","doi":"10.1016/j.jbiomech.2026.113196","DOIUrl":null,"url":null,"abstract":"<div><div>Ultrasound-based non-invasive intracranial pressure (ICP) monitoring is of significance in neurological surgery, but its core limitation lies in the mechanical mechanisms of brain tissue’s response to pressure, which have not been fully elucidated. This study aimed to clarify the acoustic responses of brain tissue under changing pressures using a hydrostatic pressure system. The ultrasonic speed and the attenuation coefficient were quantified via the Acoustic Pulse Transmission (APT) method at broad frequencies (0.1–2.0 MHz). Results demonstrated that the ultrasonic speed increased nonlinearly with hydrostatic pressure, rising from 1539 ± 6 m·s<sup>−1</sup> at baseline (0 kPa) to 1548 ± 6 m·s<sup>−1</sup> at 9 kPa, whereas the attenuation coefficient was frequency-dependent but pressure-independent. These findings indicate that the quantified relationship between ultrasonic speed and hydrostatic pressure establishes a biophysical basis for the feasibility of ultrasound-based ICP estimation.</div></div>","PeriodicalId":15168,"journal":{"name":"Journal of biomechanics","volume":"198 ","pages":"Article 113196"},"PeriodicalIF":2.9000,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomechanics","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0021929026000515","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/6 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOPHYSICS","Score":null,"Total":0}

引用次数: 0

Abstract

Ultrasound-based non-invasive intracranial pressure (ICP) monitoring is of significance in neurological surgery, but its core limitation lies in the mechanical mechanisms of brain tissue’s response to pressure, which have not been fully elucidated. This study aimed to clarify the acoustic responses of brain tissue under changing pressures using a hydrostatic pressure system. The ultrasonic speed and the attenuation coefficient were quantified via the Acoustic Pulse Transmission (APT) method at broad frequencies (0.1–2.0 MHz). Results demonstrated that the ultrasonic speed increased nonlinearly with hydrostatic pressure, rising from 1539 ± 6 m·s⁻¹ at baseline (0 kPa) to 1548 ± 6 m·s⁻¹ at 9 kPa, whereas the attenuation coefficient was frequency-dependent but pressure-independent. These findings indicate that the quantified relationship between ultrasonic speed and hydrostatic pressure establishes a biophysical basis for the feasibility of ultrasound-based ICP estimation.

查看原文本刊更多论文

脑组织的静水压相关声学特性及其在无创ICP监测中的意义。

超声无创颅内压监测在神经外科手术中具有重要意义，但其核心局限性在于脑组织对压力反应的力学机制尚未完全阐明。本研究旨在利用静水压力系统澄清脑组织在变化压力下的声学反应。在宽频（0.1 ~ 2.0 MHz）范围内，采用声波脉冲传输（APT）法对超声速度和衰减系数进行量化。结果表明：超声声速随静水压力的增大呈非线性增长，从基线（0 kPa）时的1539±6 m·s-1上升到9 kPa时的1548±6 m·s-1，衰减系数与静水压力无关，与频率有关；这些结果表明，超声速度与静水压力之间的定量关系为超声ICP估计的可行性奠定了生物物理基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of biomechanics 生物-工程：生物医学

CiteScore

5.10

自引率

4.20%

发文量

345

审稿时长

1 months

期刊介绍： The Journal of Biomechanics publishes reports of original and substantial findings using the principles of mechanics to explore biological problems. Analytical, as well as experimental papers may be submitted, and the journal accepts original articles, surveys and perspective articles (usually by Editorial invitation only), book reviews and letters to the Editor. The criteria for acceptance of manuscripts include excellence, novelty, significance, clarity, conciseness and interest to the readership. Papers published in the journal may cover a wide range of topics in biomechanics, including, but not limited to: -Fundamental Topics - Biomechanics of the musculoskeletal, cardiovascular, and respiratory systems, mechanics of hard and soft tissues, biofluid mechanics, mechanics of prostheses and implant-tissue interfaces, mechanics of cells. -Cardiovascular and Respiratory Biomechanics - Mechanics of blood-flow, air-flow, mechanics of the soft tissues, flow-tissue or flow-prosthesis interactions. -Cell Biomechanics - Biomechanic analyses of cells, membranes and sub-cellular structures; the relationship of the mechanical environment to cell and tissue response. -Dental Biomechanics - Design and analysis of dental tissues and prostheses, mechanics of chewing. -Functional Tissue Engineering - The role of biomechanical factors in engineered tissue replacements and regenerative medicine. -Injury Biomechanics - Mechanics of impact and trauma, dynamics of man-machine interaction. -Molecular Biomechanics - Mechanical analyses of biomolecules. -Orthopedic Biomechanics - Mechanics of fracture and fracture fixation, mechanics of implants and implant fixation, mechanics of bones and joints, wear of natural and artificial joints. -Rehabilitation Biomechanics - Analyses of gait, mechanics of prosthetics and orthotics. -Sports Biomechanics - Mechanical analyses of sports performance.