A Lightweight Skin-Adhesive Fiber Bragg Grating Sensor to Advance Minimally Invasive Healthcare Monitoring

IF 4.8 Q2 ENGINEERING, BIOMEDICAL
Advanced Nanobiomed Research Pub Date : 2026-02-02 Epub Date: 2025-11-12 DOI:10.1002/anbr.202500213
Ilaria Condò, Marcella Trombetta, Emiliano Schena, Daniela Lo Presti, Sara Maria Giannitelli
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Abstract

Wearable sensors that combine high precision with conformability and skin adhesion are crucial for reliable and highly unobtrusive physiological monitoring. In this context, increasing efforts are directed toward next-generation miniaturized self-adhesive sensors employing different sensing technologies. Herein, for the first time a self-adhesive sensor is developed for real-time detection of physiological and biomechanical strain signals, by embedding a fiber Bragg grating (FBG) sensor into a soft, biomimetic, flexible matrix. This hydrogel-based matrix, composed of gelatin methacrylate, xanthan gum, and glycerol, is engineered to balance fiber–matrix mechanical coupling and skin adhesion. The encapsulated FBG sensor exhibits stable optical response, reduced signal attenuation, and retains good sensitivity to both strain (0.07 nm mε−1) and temperature (0.01 nm °C−1). Preliminary on-skin tests on a healthy volunteer demonstrate the ability to capture subtle physiological signals such as breathing and heartbeats, as well as limb motion. Notably, the self-adhesive properties of the matrix enable firm skin contact without additional tapes, enhancing signal reliability, and reducing motion artifacts. This approach offers a robust, biocompatible, and scalable solution for wearable sensing, opening new opportunities in health monitoring, rehabilitation, and human–machine interfaces.

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一种轻量皮肤粘合光纤光栅传感器,以推进微创医疗监测
结合高精度、适应性和皮肤粘附性的可穿戴传感器对于可靠和高度不显眼的生理监测至关重要。在这种情况下,越来越多的努力是针对采用不同传感技术的下一代小型化自粘传感器。本文首次开发了一种用于实时检测生理和生物力学应变信号的自粘附传感器,该传感器通过将光纤布拉格光栅(FBG)传感器嵌入柔软的仿生柔性矩阵中。这种以水凝胶为基础的基质,由甲基丙烯酸明胶、黄原胶和甘油组成,旨在平衡纤维基质的机械耦合和皮肤粘附性。封装后的光纤光栅传感器具有稳定的光学响应,减小了信号衰减,并且对应变(0.07 nm mε−1)和温度(0.01 nm°C−1)都保持良好的灵敏度。在一名健康志愿者身上进行的初步皮肤测试表明,该设备能够捕捉细微的生理信号,如呼吸和心跳,以及肢体运动。值得注意的是,该矩阵的自粘特性使皮肤接触牢固,无需额外的胶带,增强信号可靠性,并减少运动伪影。这种方法为可穿戴传感提供了一种强大的、生物相容的、可扩展的解决方案,为健康监测、康复和人机界面开辟了新的机会。
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来源期刊
Advanced Nanobiomed Research
Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-
CiteScore
5.00
自引率
5.90%
发文量
87
审稿时长
21 weeks
期刊介绍: Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
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