Safety and immunogenicity of a single dose of Ad26.COV2.S, BNT162b2, or SARS-CoV-2-rS-protein-nanoparticle in previously vaccinated and unvaccinated adults living with and without HIV in South Africa: a phase 2a randomised, observer-blind trial

IF 13 1区医学 Q1 IMMUNOLOGY

Lancet Hiv Pub Date : 2026-02-11 DOI:10.1016/s2352-3018(25)00275-9

Vaneshree Govender, Tarylee Reddy, Pholo Maenetje, Trevor Beattie, Tania Adonis, Tanya Nielson, Jayajothi Moodley, John Mdluli, Aruna Bhoola, Stacey Angelo, Ravindre Panchia, Kathy Mngadi, Craig Innes, William Brumskine, Mandla Mlotshwa, Lindiwe Nhlangulela, Itai Ncube, Thandeka Moyo-Gwete, Penny L Moore, Roanne S Keeton, Wendy Burgers, Kapil Kumar, Neha Garg, Alok Tripathi, Sharfuddin Sayed, Katleho Matsimela, Nobuhle Mchunu, Robert Wallis, Vinodh A Edward, Gavin J Churchyard, Mamothedi Tebatso Tshwana, Keitumetsi Moreki, Zithelo Zikalala, Magotso Pearl Makola, Nondumiso Vester Masango, Precious Nomsa Mofokeng, Louise Pretorius, Mponeng Mathobela Molepo, Fortune Mokhomola, Aifheli Marcia Masevhe, Manasa Mapendere, Mogafe Lucia Mokaba, Hanlie Veldsman, Carita Marx, Amukelani Tshabalala, Malebo Pertunia Mahlalela, Mpho Netshongolwe, Mpho Tshabalala, Letlhogonolo Rosemary Moleoa, Poelano Hope Mashile, Duduzile Gumede, Trisha Munsamy, Mandisa Nkosi, Lindelwa Nkangane, Bonolo Mntungwa, Monicah Thabisile Mbonani, Johan Riaan Jordaan, Maporene Andries Sebopa, Thandiwe Rosemary Maseko, Rose Ntavasi Nkanyane, Jerlyn Benyera, Thompho Mugwena, Emily Kekana, Ephriam Mmalekutu Pilusa, Sizakele Christobel Dlamini, Pardon Kamogelo Kgaladi, Malobisa Sylvester Magwasha, Samkelo Moloi, Themba Phakathi, Tlhago Elias Ngwanto, Dapheney Tiyiselani Mashele, Rirhandzu Pollet Rikhotso, Nhlamulo Baloyi, Christinah Nthathane Nke, Elizabeth Barbara Janse Van Rensburg, Amanda Van Aswegen, Madile Lillian Batsietseng, Mmanare Maria Tlhapi, Oteng Letlape, Tebogo Rampai, Pontsho Motsatse, Nthabiseng Mofube, Lebogang Moletashope, Primrose Mothaga, Precious Lebatsi, Lucky Letlhogonolo Dhlamini, Tshohanyetso Mosoahle, Thelma Goliath, Letlhogonolo Seabela, Seleke Maroo, Thapelo Chele, Marelize Collignon, Adriane Kock, Immaculate Mabasa, James Craig Innes, Thato Cherity Mohlala, Aphiwe Tshwati, Ken Clarke, Nondumiso Langa, Palesa Mosweu, Maditaba Anna Ramokanate, Tshepo Baba, Temoso Masenya, Aneesa Lakhi, Mgcini Moyo, Lezaan-Marie Smit, Kesenogile Baepanye, Welhemina Jonkane, Selvy Samoele Matshego, Thandiwe Papalagae, Busisiwe Xhamagele, Lindiwe Rosetta Nhlangulela, Graciano Market, Obakeng Violet Mokotedi, Nkosinathi Charles Mabuza, Moleboheng Belina Motsiri, Keatlegile Phumlani Motswenyane, Katlego Mooketsi, Masabata Veronica Sekgonyane, Tanya Nielson, Marthinette Taljaard, William Lawrence Brumskine, Ni Ni Sein, Tiro Amos Dinake, Phillip Mafori Mphahlele, Siyabonga Nhlapo, Ireen Lesebang Mosweu, Lesego Lucky Molosiwa, Themba Phakathi, Chantal Onkgopotse Molotsi, Kabelo Mabeleng, Gloria Keitumetse Kolobe, Patient Madidimalo Machaba, Dipuo Sebese, Mabika Christian Kasongo, Sifiso Cornelius Shezi, Caroline Mokhoko, Karabo Believer Morebodi, Tshegofatso Dorah Moloatsi, Lethabo Colleen Theko, Ellen Matsane, Mando Mmakhora Thaba, Lerato Julia Block, Seasebeng Pertunia Mothobi, Perfect Tiisetso Malope, Tshegofatso Magnus Ramatlhape, Precy Mashele, Gloria Mmoge Mataboge, Joan Nyanghongo, Emilia de Klerk, Banyana Olga Motlagomang, Kgomotso Abegail Mokotedi, Nisha Naidoo, Rendani Helen Ngwagwe, Susan Vermaak, Sefolo Moses Kgaphola, Bonolo Pearl Mabebe, Melissa Neo Senne, Brenda Modisaotsile, Kgothatso Precious Tau, Engela du Plooy, Aluwani Adolf Thovhakale, Kamogelo Fortunate Matlhase, Mmarona Elizabeth Lekalakala, Boikago Lekotloane Lekalakala, Boitumelo Modisaotsile, Likhapha Monica Pule, Esme Venter, Zwelethu Zwane, Nicole Glover, Liezl Nel, Henriette Bam, Innocent Shibambo, Queen Thaba, Nkateko Maringa, Rebaona Legoale, Molebogeng Nkete, Tsholofelo Moagi, Thilivhali Mulaudzi, Thandeka Mpontshane, Dinah Pambo, Refiloe Masemola, Mandisa Nyanya, Kathryn Therese Mngadi, Anja Nanine Henning, Mashudu Brian Mahlangu, Sabiha Shaik, Rujeko Mashingaidze, Yajna Duki, Sibekezelo Msomi, Tshiamo Moela, Calvin Kgaphol, Kgopotso Mojela, Nomagugu Sibanda, Abram Nhlapo, Thando Mkhaliphi, Zanele Rachel Skosana, Nolwazi Mahlangu, Mashudu Siebani, Pule Msibi, Vincent Tshikovhi, Sizakele Christobel Dlamini, Happiness Thulile Mthalane, Elia Motwanama, Elliot Lesiba Ramokolo, Sindisiwe Sibiya, Nontsikelelo Hamnca, Zandiswa Kula, Nelisa Mboto, Bontle Mapoma, Dineo Rammutla, Nthabiseng Khoza, Pardon Kamogelo Kgaladi, Tumelo Moorosi, Moyahabo Faith Molapo, Tshifaro Nedzingahe, Busisiwe Mpila, Khuthadzo Hlongwane, Emily Lebotsa, Paballo Mosala, Maxine A Höft, Millicent A Omondi, Rofhiwa Nesamari, Ntombi Benede, Richard Baguma, Asiphe S Besethi, Siyabulela FJ Magugu, Amkele Ngomti, Anathi A Nkayi, Avril Walters, Sashkia R Balla, Qiniso Mkhize, Anbalagan Anantharaj, Parveen Singh, Pooja Kumari Shashi, Akshita Garg, Josephine H Cox, Wayne C Koff, Rym Ben Othman, Arnaud Marchant, Coralie Henin, John Altin, Heather Mead, Erin Kelley, Phillip Felgner, Rie Nakajima, Rafael Ramiro De Assis

{"title":"Safety and immunogenicity of a single dose of Ad26.COV2.S, BNT162b2, or SARS-CoV-2-rS-protein-nanoparticle in previously vaccinated and unvaccinated adults living with and without HIV in South Africa: a phase 2a randomised, observer-blind trial","authors":"Vaneshree Govender, Tarylee Reddy, Pholo Maenetje, Trevor Beattie, Tania Adonis, Tanya Nielson, Jayajothi Moodley, John Mdluli, Aruna Bhoola, Stacey Angelo, Ravindre Panchia, Kathy Mngadi, Craig Innes, William Brumskine, Mandla Mlotshwa, Lindiwe Nhlangulela, Itai Ncube, Thandeka Moyo-Gwete, Penny L Moore, Roanne S Keeton, Wendy Burgers, Kapil Kumar, Neha Garg, Alok Tripathi, Sharfuddin Sayed, Katleho Matsimela, Nobuhle Mchunu, Robert Wallis, Vinodh A Edward, Gavin J Churchyard, Mamothedi Tebatso Tshwana, Keitumetsi Moreki, Zithelo Zikalala, Magotso Pearl Makola, Nondumiso Vester Masango, Precious Nomsa Mofokeng, Louise Pretorius, Mponeng Mathobela Molepo, Fortune Mokhomola, Aifheli Marcia Masevhe, Manasa Mapendere, Mogafe Lucia Mokaba, Hanlie Veldsman, Carita Marx, Amukelani Tshabalala, Malebo Pertunia Mahlalela, Mpho Netshongolwe, Mpho Tshabalala, Letlhogonolo Rosemary Moleoa, Poelano Hope Mashile, Duduzile Gumede, Trisha Munsamy, Mandisa Nkosi, Lindelwa Nkangane, Bonolo Mntungwa, Monicah Thabisile Mbonani, Johan Riaan Jordaan, Maporene Andries Sebopa, Thandiwe Rosemary Maseko, Rose Ntavasi Nkanyane, Jerlyn Benyera, Thompho Mugwena, Emily Kekana, Ephriam Mmalekutu Pilusa, Sizakele Christobel Dlamini, Pardon Kamogelo Kgaladi, Malobisa Sylvester Magwasha, Samkelo Moloi, Themba Phakathi, Tlhago Elias Ngwanto, Dapheney Tiyiselani Mashele, Rirhandzu Pollet Rikhotso, Nhlamulo Baloyi, Christinah Nthathane Nke, Elizabeth Barbara Janse Van Rensburg, Amanda Van Aswegen, Madile Lillian Batsietseng, Mmanare Maria Tlhapi, Oteng Letlape, Tebogo Rampai, Pontsho Motsatse, Nthabiseng Mofube, Lebogang Moletashope, Primrose Mothaga, Precious Lebatsi, Lucky Letlhogonolo Dhlamini, Tshohanyetso Mosoahle, Thelma Goliath, Letlhogonolo Seabela, Seleke Maroo, Thapelo Chele, Marelize Collignon, Adriane Kock, Immaculate Mabasa, James Craig Innes, Thato Cherity Mohlala, Aphiwe Tshwati, Ken Clarke, Nondumiso Langa, Palesa Mosweu, Maditaba Anna Ramokanate, Tshepo Baba, Temoso Masenya, Aneesa Lakhi, Mgcini Moyo, Lezaan-Marie Smit, Kesenogile Baepanye, Welhemina Jonkane, Selvy Samoele Matshego, Thandiwe Papalagae, Busisiwe Xhamagele, Lindiwe Rosetta Nhlangulela, Graciano Market, Obakeng Violet Mokotedi, Nkosinathi Charles Mabuza, Moleboheng Belina Motsiri, Keatlegile Phumlani Motswenyane, Katlego Mooketsi, Masabata Veronica Sekgonyane, Tanya Nielson, Marthinette Taljaard, William Lawrence Brumskine, Ni Ni Sein, Tiro Amos Dinake, Phillip Mafori Mphahlele, Siyabonga Nhlapo, Ireen Lesebang Mosweu, Lesego Lucky Molosiwa, Themba Phakathi, Chantal Onkgopotse Molotsi, Kabelo Mabeleng, Gloria Keitumetse Kolobe, Patient Madidimalo Machaba, Dipuo Sebese, Mabika Christian Kasongo, Sifiso Cornelius Shezi, Caroline Mokhoko, Karabo Believer Morebodi, Tshegofatso Dorah Moloatsi, Lethabo Colleen Theko, Ellen Matsane, Mando Mmakhora Thaba, Lerato Julia Block, Seasebeng Pertunia Mothobi, Perfect Tiisetso Malope, Tshegofatso Magnus Ramatlhape, Precy Mashele, Gloria Mmoge Mataboge, Joan Nyanghongo, Emilia de Klerk, Banyana Olga Motlagomang, Kgomotso Abegail Mokotedi, Nisha Naidoo, Rendani Helen Ngwagwe, Susan Vermaak, Sefolo Moses Kgaphola, Bonolo Pearl Mabebe, Melissa Neo Senne, Brenda Modisaotsile, Kgothatso Precious Tau, Engela du Plooy, Aluwani Adolf Thovhakale, Kamogelo Fortunate Matlhase, Mmarona Elizabeth Lekalakala, Boikago Lekotloane Lekalakala, Boitumelo Modisaotsile, Likhapha Monica Pule, Esme Venter, Zwelethu Zwane, Nicole Glover, Liezl Nel, Henriette Bam, Innocent Shibambo, Queen Thaba, Nkateko Maringa, Rebaona Legoale, Molebogeng Nkete, Tsholofelo Moagi, Thilivhali Mulaudzi, Thandeka Mpontshane, Dinah Pambo, Refiloe Masemola, Mandisa Nyanya, Kathryn Therese Mngadi, Anja Nanine Henning, Mashudu Brian Mahlangu, Sabiha Shaik, Rujeko Mashingaidze, Yajna Duki, Sibekezelo Msomi, Tshiamo Moela, Calvin Kgaphol, Kgopotso Mojela, Nomagugu Sibanda, Abram Nhlapo, Thando Mkhaliphi, Zanele Rachel Skosana, Nolwazi Mahlangu, Mashudu Siebani, Pule Msibi, Vincent Tshikovhi, Sizakele Christobel Dlamini, Happiness Thulile Mthalane, Elia Motwanama, Elliot Lesiba Ramokolo, Sindisiwe Sibiya, Nontsikelelo Hamnca, Zandiswa Kula, Nelisa Mboto, Bontle Mapoma, Dineo Rammutla, Nthabiseng Khoza, Pardon Kamogelo Kgaladi, Tumelo Moorosi, Moyahabo Faith Molapo, Tshifaro Nedzingahe, Busisiwe Mpila, Khuthadzo Hlongwane, Emily Lebotsa, Paballo Mosala, Maxine A Höft, Millicent A Omondi, Rofhiwa Nesamari, Ntombi Benede, Richard Baguma, Asiphe S Besethi, Siyabulela FJ Magugu, Amkele Ngomti, Anathi A Nkayi, Avril Walters, Sashkia R Balla, Qiniso Mkhize, Anbalagan Anantharaj, Parveen Singh, Pooja Kumari Shashi, Akshita Garg, Josephine H Cox, Wayne C Koff, Rym Ben Othman, Arnaud Marchant, Coralie Henin, John Altin, Heather Mead, Erin Kelley, Phillip Felgner, Rie Nakajima, Rafael Ramiro De Assis","doi":"10.1016/s2352-3018(25)00275-9","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"85 1","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lancet Hiv","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/s2352-3018(25)00275-9","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

查看原文本刊更多论文

单剂Ad26.COV2的安全性和免疫原性。S、BNT162b2或sars - cov -2- rs蛋白纳米颗粒在南非以前接种过疫苗和未接种过疫苗的感染和不感染艾滋病毒的成年人中的作用：一项2a期随机、观察者盲试验

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Lancet Hiv IMMUNOLOGYINFECTIOUS DISEASES&-INFECTIOUS DISEASES

CiteScore

19.90

自引率

4.30%

发文量

368

期刊介绍： The Lancet HIV is an internationally trusted source of clinical, public health, and global health knowledge with an Impact Factor of 16.1. It is dedicated to publishing original research, evidence-based reviews, and insightful features that advocate for change in or illuminates HIV clinical practice. The journal aims to provide a holistic view of the pandemic, covering clinical, epidemiological, and operational disciplines. It publishes content on innovative treatments and the biological research behind them, novel methods of service delivery, and new approaches to confronting HIV/AIDS worldwide. The Lancet HIV publishes various types of content including articles, reviews, comments, correspondences, and viewpoints. It also publishes series that aim to shape and drive positive change in clinical practice and health policy in areas of need in HIV. The journal is indexed by several abstracting and indexing services, including Crossref, Embase, Essential Science Indicators, MEDLINE, PubMed, SCIE and Scopus.