Effects of different dietary restriction regimens on cognitive function and pathological markers in Alzheimer's disease mouse models: A systematic review and meta-analysis

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES

Neuroscience and Biobehavioral Reviews Pub Date : 2026-05-01 Epub Date: 2026-02-08 DOI:10.1016/j.neubiorev.2026.106601

Lirui Sun , Xinyi Xu , Zihan Wang , Yuhan Meng , Ye Li , Yumeng Hou , Xiaohui Gao , Huixian Cui , Yan Li

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引用次数: 0

Abstract

Dietary restriction (DR) has emerged as a promising non-pharmacological intervention for Alzheimer’s disease (AD). This systematic review and meta-analysis provides the first comprehensive comparison of five dietary restriction regimens in Alzheimer's disease mouse models. Analysis of 23 studies demonstrates that caloric restriction yields the most consistent benefits. While intermittent fasting exhibits model-dependent efficacy—improving recognition memory but exacerbating neuroinflammation in 5 ×FAD models. The fasting-mimicking diet showed the largest effect size. From a geroscience perspective, these findings support a precision nutrition framework for Alzheimer's disease, suggesting that future interventions should be tailored to individual pathological profile, inflammatory status, and impaired cognitive subdomains to optimize therapeutic efficacy.

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不同饮食限制方案对阿尔茨海默病小鼠模型认知功能和病理标志物的影响：系统综述和荟萃分析

饮食限制（DR）已成为治疗阿尔茨海默病（AD）的一种很有前途的非药物干预方法。本系统综述和荟萃分析首次对阿尔茨海默病小鼠模型中的五种饮食限制方案进行了全面比较。对23项研究的分析表明，热量限制带来的益处最为一致。而间歇性禁食表现出模型依赖的功效-在5×FAD模型中改善识别记忆但加剧神经炎症。模拟禁食饮食的效果最大。从老年科学的角度来看，这些发现支持了阿尔茨海默病的精确营养框架，表明未来的干预措施应该针对个体病理特征、炎症状态和受损的认知亚域进行定制，以优化治疗效果。

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来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.