Association of FIB-4 with orthostatic hypotension in Parkinson's disease

IF 2.7 4区医学 Q2 NEUROSCIENCES

Autonomic Neuroscience-Basic & Clinical Pub Date : 2026-04-01 Epub Date: 2026-02-04 DOI:10.1016/j.autneu.2026.103390

Wen Zhou , Tianfang Zeng , Duan Liu , Ruijuan Pang , Liang Gong

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引用次数: 0

Abstract

Background

Orthostatic hypotension (OH) is a common complication in Parkinson's disease (PD) patients, significantly impacting their quality of life. Recent evidence suggests a potential link between liver fibrosis, indicated by the Fibrosis-4 (FIB-4) index, and autonomic dysfunction. However, its relationship with OH in PD remains unexplored.

Methods

A cross-sectional analysis was conducted using data from 1268 PD patients. The FIB-4 index was calculated based on age, AST, ALT, and platelet count. The association between FIB-4 and OH was assessed using multivariate logistic regression, with further curve fitting and subgroup analyses to test robustness.

Results

The FIB-4 index was significantly associated with OH. For each 0.2-unit increase in FIB-4, the odds ratio (OR) for OH was 1.11 (95% CI: 1.05–1.17, p < 0.001). Tertile analysis showed ORs of 2.05 (95% CI: 1.27–3.31, p = 0.003) for T2 and 2.61 (95% CI: 1.64–4.17, p < 0.001) for T3, compared to T1. Curve fitting indicated a linear relationship, with no evidence of non-linearity. Sensitivity and subgroup analyses confirmed robustness.

Conclusions

Higher FIB-4 index values are independently associated with an increased risk of OH in PD patients, suggesting that liver fibrosis may contribute to OH development. Further longitudinal studies are needed to explore the underlying mechanisms.

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FIB-4与帕金森病患者体位性低血压的关系

背景：直立性低血压（OH）是帕金森病（PD）患者的常见并发症，严重影响其生活质量。最近的证据表明肝纤维化（由纤维化-4 （FIB-4）指数显示）与自主神经功能障碍之间存在潜在联系。然而，其与PD中OH的关系尚不清楚。方法：对1268例PD患者资料进行横断面分析。FIB-4指数根据年龄、AST、ALT和血小板计数计算。FIB-4与OH之间的关系采用多变量逻辑回归进行评估，并进一步进行曲线拟合和亚组分析以检验稳健性。结果：FIB-4指数与OH有显著相关性。FIB-4每增加0.2个单位，OH的优势比（OR）为1.11 （95% CI: 1.05-1.17, p）。结论：较高的FIB-4指数值与PD患者OH风险增加独立相关，提示肝纤维化可能促进OH的发展。需要进一步的纵向研究来探索潜在的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autonomic Neuroscience-Basic & Clinical 医学-神经科学

CiteScore

5.80

自引率

7.40%

发文量

审稿时长

66 days

期刊介绍： This is an international journal with broad coverage of all aspects of the autonomic nervous system in man and animals. The main areas of interest include the innervation of blood vessels and viscera, autonomic ganglia, efferent and afferent autonomic pathways, and autonomic nuclei and pathways in the central nervous system. The Editors will consider papers that deal with any aspect of the autonomic nervous system, including structure, physiology, pharmacology, biochemistry, development, evolution, ageing, behavioural aspects, integrative role and influence on emotional and physical states of the body. Interdisciplinary studies will be encouraged. Studies dealing with human pathology will be also welcome.