The Geoepidemiology of Autoimmune Hepatitis.

IF 11.5 2区医学 Q1 ALLERGY

Clinical Reviews in Allergy & Immunology Pub Date : 2026-02-11 DOI:10.1007/s12016-026-09138-6

Yang Li, Xiangzhen Meng, Patrick S C Leung, M Eric Gershwin, Diego Vergani, Junmin Song

引用次数: 0

Abstract

Autoimmune hepatitis (AIH) is typically a chronic, inflammatory, and progressive liver disease of autoimmune origin. Currently, two recognized types are identified in clinical practice: type 1 and type 2. The disease can occur in all geographic regions and racial/ethnic groups worldwide, but shows marked variations. This pattern reflects a complex interplay between genetic factors and environmental triggers. In this review, we aim to examine the geoepidemiological features of AIH and explore how these features relate to its etiopathogenesis, providing an integrated analysis of this complex condition. Our work may shed light on the initiation and progression of AIH, as well as its treatment and prevention.

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自身免疫性肝炎的地理流行病学研究

自身免疫性肝炎（AIH）是一种典型的慢性、炎症性和进行性自身免疫性肝病。目前，临床实践中确定了两种公认的类型：1型和2型。该病可发生于全球所有地理区域和种族/族裔群体，但表现出明显的差异。这种模式反映了遗传因素和环境因素之间复杂的相互作用。在这篇综述中，我们旨在研究AIH的地理流行病学特征，并探讨这些特征与其发病机制的关系，为这一复杂疾病提供综合分析。我们的工作可能会揭示艾滋病的开始和发展，以及它的治疗和预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Reviews in Allergy & Immunology 医学-过敏

CiteScore

22.30

自引率

1.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.