{"title":"Recent Discovery on Metal-Free Construction of S-Aryl Phosphorothioate Diesters","authors":"Jayshree Nandkumar Solanke, Savita Gat, Rambabu Dandela, Vasudevan Dhayalan","doi":"10.1002/ijch.70008","DOIUrl":null,"url":null,"abstract":"<p>Recent innovations in metal-free phosphorothioate synthesis have underscored increased utility as a sustainable alternative to metal-catalyzed procedures. Green approaches, such as metal-free coupling reactions and oxidations, radical-induced methods, electrochemical processes, and multicomponent reactions, were reported from 2020 to 2025 for the successful development of S-aryl phosphorothioates and S-heterocyclic phosphorothioates. These methods involve high atom economy, broad functional group tolerance, and mechanistic studies, positioning metal-free phosphorothiolation as an emergent tool of power and sustainability in modern organic synthesis under a green system.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":"66 1","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Israel Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ijch.70008","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Recent innovations in metal-free phosphorothioate synthesis have underscored increased utility as a sustainable alternative to metal-catalyzed procedures. Green approaches, such as metal-free coupling reactions and oxidations, radical-induced methods, electrochemical processes, and multicomponent reactions, were reported from 2020 to 2025 for the successful development of S-aryl phosphorothioates and S-heterocyclic phosphorothioates. These methods involve high atom economy, broad functional group tolerance, and mechanistic studies, positioning metal-free phosphorothiolation as an emergent tool of power and sustainability in modern organic synthesis under a green system.
期刊介绍：
The fledgling State of Israel began to publish its scientific activity in 1951 under the general heading of Bulletin of the Research Council of Israel, which quickly split into sections to accommodate various fields in the growing academic community. In 1963, the Bulletin ceased publication and independent journals were born, with Section A becoming the new Israel Journal of Chemistry.
The Israel Journal of Chemistry is the official journal of the Israel Chemical Society. Effective from Volume 50 (2010) it is published by Wiley-VCH.
The Israel Journal of Chemistry is an international and peer-reviewed publication forum for Special Issues on timely research topics in all fields of chemistry: from biochemistry through organic and inorganic chemistry to polymer, physical and theoretical chemistry, including all interdisciplinary topics. Each topical issue is edited by one or several Guest Editors and primarily contains invited Review articles. Communications and Full Papers may be published occasionally, if they fit with the quality standards of the journal. The publication language is English and the journal is published twelve times a year.
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