Moxibustion for chemotherapy-induced myelosuppression: A systematic review and meta-analysis

IF 1.3 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

World Journal of Acupuncture-Moxibustion Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI:10.1016/j.wjam.2025.12.001

Dan XUE (薛丹) , Rong-lin LAN (蓝荣林) , Hua-tao HU (胡华涛) , Yun-bin ZHANG (张云彬) , Xian-bao HUANG (黄仙保)

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引用次数: 0

Abstract

Objective

To evaluate the effectiveness and safety of moxibustion for chemotherapy-induced myelosuppression.

Methods

The randomized controlled trials of moxibustion for chemotherapy-induced myelosuppression were searched in PubMed, Cochrane Library, Web of Science, Embase, China Journal Full-text Database, SinoMed, Wanfang Data Knowledge Service Platform, and VIP Chinese Journal Service Platform, from the inception of each database to July 30, 2024. RevMan5.3 and Stata18.0 were used for meta-analysis, and the quality of included literature was evaluated by Cochrane Risk of Bias (RoB) assessment tool.

Results

A total of 19 articles were included. Moxibustion can increase white blood cell count (MD = 1.06, 95 % CI: 0.45–1.68, P = 0.0007), platelet count (MD = 32.02, 95 % CI: 16.33–47.72, P < 0.00001), hemoglobin content (MD = 5.57, 95 % CI: 1.61–9.53, P = 0.006) and neutrophil count (MD = 1.20, 95 % CI: 0.94–1.45, P < 0.00001). Moxibustion could alleviate chemotherapy-induced myelosuppression (RR = 0.70, 95 % CI: 0.56–0.86, P = 0.0007), reduced the incidences of leukopenia (RR = 0.39, 95 % CI: 0.26–0.59, P < 0.000001) and thrombocytopenia (RR = 0.33, 95 % CI: 0.21–0.53, P < 0.000001), and can improve the score of quality of life (MD = 0.55, 95 % CI: 0.32–0.79, P < 0.00001).

Conclusion

Moxibustion can increase the white blood cell count, platelet count, hemoglobin content and neutrophil count of patients after chemotherapy, alleviate myelosuppression, and the incidences of leukopenia and thrombocytopenia induced by chemotherapy, and improve the quality of life. Moxibustion is effective and safe for chemotherapy-induced myelosuppression. However, due to the relatively low quality of included studies, there are certain limitations. More high-quality studies are needed in the future to provide more reliable evidence-based basis for clinical practice.

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艾灸治疗化疗诱导的骨髓抑制：系统回顾和荟萃分析

目的评价艾灸治疗化疗所致骨髓抑制的有效性和安全性。方法检索PubMed、Cochrane图书馆、Web of Science、Embase、中国期刊全文数据库、中国医学信息网、万方数据知识服务平台、VIP中文期刊服务平台自各数据库建立至2024年7月30日的随机对照试验资料，检索艾灸治疗化疗诱导骨髓抑制的相关文献。采用RevMan5.3和Stata18.0进行meta分析，采用Cochrane风险偏倚（RoB）评估工具评价纳入文献的质量。结果共纳入文献19篇。艾灸可提高白细胞计数（MD = 1.06, 95% CI: 0.45 ~ 1.68, P = 0.0007）、血小板计数（MD = 32.02, 95% CI: 16.33 ~ 47.72, P = 0.00001）、血红蛋白含量（MD = 5.57, 95% CI: 1.61 ~ 9.53, P = 0.006）、中性粒细胞计数（MD = 1.20, 95% CI: 0.94 ~ 1.45, P = 0.00001）。艾灸可减轻化疗诱导的骨髓抑制（RR = 0.70, 95% CI: 0.56 ~ 0.86, P = 0.0007），降低白细胞减少（RR = 0.39, 95% CI: 0.26 ~ 0.59, P < 0.000001）和血小板减少（RR = 0.33, 95% CI: 0.21 ~ 0.53, P < 0.000001）的发生率，提高生活质量评分（MD = 0.55, 95% CI: 0.32 ~ 0.79, P < 0.00001）。结论艾灸可提高化疗后患者白细胞计数、血小板计数、血红蛋白含量和中性粒细胞计数，减轻化疗所致骨髓抑制，降低白细胞减少和血小板减少的发生率，提高患者的生活质量。艾灸治疗化疗所致骨髓抑制有效、安全。然而，由于纳入的研究质量相对较低，存在一定的局限性。未来需要更多高质量的研究，为临床实践提供更可靠的循证依据。

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来源期刊

World Journal of Acupuncture-Moxibustion INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

1.30

自引率

28.60%

发文量

1089

审稿时长

50 days

期刊介绍： The focus of the journal includes, but is not confined to, clinical research, summaries of clinical experiences, experimental research and clinical reports on needling techniques, moxibustion techniques, acupuncture analgesia and acupuncture anesthesia.