Evaluation of the ivermectin effects on porcine granulosa cell function

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2026-04-01 Epub Date: 2026-02-10 DOI:10.1016/j.etap.2026.104960

Giuseppina Basini, Fausto Quintavalla, Simona Bussolati, Francesca Grasselli

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引用次数: 0

Abstract

Ivermectin (IVM) is used as antiparasitic drug in veterinary medicine and it is also the only avermectin approved in humans in several parasitic infestations. We examined this substance because potential critical issues associated with the use were highlighted. Moreover, criticisms related to the ecological-environmental sphere, as well as food contamination arise. Nevertheless, current in vitro studies are lacking. This study aimed to investigate the direct impact of IVM on reproductive function using swine granulosa cells as reproductive cell model. The results show that progesterone, ATP and free radicals’ levels significantly increased (p < 0.05). Non-enzymatic defense systems as well as autophagy did not show significant differences. On the contrary, cell proliferation, estradiol levels, and enzymatic defense systems significantly decreased (p < 0.05) after IVM treatment. Since results show that the normal function of these cells is compromised by IVM the normal reproductive functions of the entire organism could be disrupted.

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伊维菌素对猪颗粒细胞功能影响的评价

伊维菌素（IVM）是兽医学中常用的抗寄生虫药物，也是在几种寄生虫感染中唯一被批准用于人类的阿维菌素。我们检查了这种物质，因为与使用相关的潜在关键问题得到了强调。此外，还出现了与生态环境领域以及食品污染有关的批评。然而，目前缺乏体外研究。本研究以猪颗粒细胞为生殖细胞模型，探讨IVM对猪生殖功能的直接影响。结果表明，黄体酮、ATP和自由基水平显著升高（p < 0.05）。非酶防御系统和自噬没有显著差异。相反，IVM处理后细胞增殖、雌二醇水平和酶防御系统显著降低（p < 0.05）。由于研究结果表明这些细胞的正常功能受到IVM的损害，整个生物体的正常生殖功能可能受到破坏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.