Fungal meningoencephalitis caused by Phanerochaete sp.: Case report

IF 1.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI:10.1016/j.mmcr.2026.100767

Juan Sebastián Sánchez León , Michel Cristian Grasel , Cecília Bittencourt Severo , Heryk Motta , Júlia Catarina Vieira Reuwsaat , Lívia Kmetzsch , Guilherme Girardi May , Paulo Renato Petersen Behar , Alessandro C. Pasqualotto , Carlos Roberto de Mello Rieder

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Abstract

We report the first case of fungal meningoencephalitis caused by Phanerochaete sp. in a previously healthy 51-year-old woman. The patient presented with progressive neurological decline and abnormal cerebrospinal fluid (CSF) findings. Neuroimaging suggested fungal infection, but conventional diagnostics were negative. Subsequently, fungal growth was obtained from CSF culture, and the isolate was identified as Phanerochaete sp. by DNA sequencing, an environmental basidiomycete not previously implicated in central nervous system disease. Antifungal therapy with voriconazole and amphotericin B led to mild clinical and radiological improvement, though significant neurological sequelae persisted. This case highlights the value of molecular diagnostics in identifying rare fungal pathogens and expanding our understanding of their pathogenic potential.

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平革菌引起的真菌性脑膜脑炎1例。

我们报告第一例真菌脑膜脑炎引起的显革杆菌在一个以前健康的51岁妇女。患者表现为进行性神经功能减退和脑脊液（CSF）异常。神经影像学提示真菌感染，但常规诊断阴性。随后，从脑脊液培养中获得真菌生长，通过DNA测序鉴定该分离物为Phanerochaete sp.，这是一种以前与中枢神经系统疾病无关的环境担子菌。伏立康唑和两性霉素B抗真菌治疗导致轻度临床和放射学改善，但显著的神经系统后遗症持续存在。该病例突出了分子诊断在鉴定罕见真菌病原体和扩大我们对其致病潜力的理解方面的价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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