Break to build: fracture as a unifying morphogenetic strategy.

IF 3.6 2区生物学 Q1 DEVELOPMENTAL BIOLOGY

Development Pub Date : 2026-08-15 Epub Date: 2026-02-09 DOI:10.1242/dev.205136

Daniel Santos-Oliván, Christopher J J Chan, Alejandro Torres-Sánchez, Rashmi Priya

引用次数: 0

Abstract

Fracture - the initiation and propagation of cracks - has long been associated with structural failure. However, active living tissues often harness fracture as a controlled morphogenetic tool due to their unique capacities to self-organise and self-repair. In this Review, we highlight how fractures are actively interpreted, integrated and functionalised within developmental programmes to sculpt tissues across scales and species. We connect core concepts from fracture mechanics, such as stress concentration, energy release and fatigue, to biological contexts, showing how tissues actively adapt these principles by remodelling their adhesion, cytoskeleton and extracellular matrix. From reversible epithelial tears to permanent organismal fission, we discuss examples in which fracture contributes to morphogenesis, homeostasis, reproduction and egress. Further, we argue for an interdisciplinary approach to understanding how fractures emerge and drive morphogenetic transitions.

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断裂构建：断裂作为一种统一的形态发生策略。

断裂——裂纹的萌生和扩展——长期以来一直与结构破坏联系在一起。然而，活跃的活体组织由于其独特的自我组织和自我修复能力，经常利用骨折作为受控的形态发生工具。在这篇综述中，我们强调了骨折是如何在发育计划中被积极地解释、整合和功能化，以塑造不同规模和物种的组织。我们将断裂力学的核心概念，如应力集中、能量释放和疲劳，与生物学背景联系起来，展示了组织如何通过重塑它们的粘附、细胞骨架和细胞外基质来积极适应这些原则。从可逆的上皮细胞撕裂到永久的有机体裂变，我们讨论了断裂有助于形态发生、体内平衡、繁殖和出口的例子。此外，我们主张采用跨学科的方法来理解裂缝如何出现并驱动形态发生转变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Development 生物-发育生物学

CiteScore

6.70

自引率

4.30%

发文量

433

审稿时长

3 months

期刊介绍： Development’s scope covers all aspects of plant and animal development, including stem cell biology and regeneration. The single most important criterion for acceptance in Development is scientific excellence. Research papers (articles and reports) should therefore pose and test a significant hypothesis or address a significant question, and should provide novel perspectives that advance our understanding of development. We also encourage submission of papers that use computational methods or mathematical models to obtain significant new insights into developmental biology topics. Manuscripts that are descriptive in nature will be considered only when they lay important groundwork for a field and/or provide novel resources for understanding developmental processes of broad interest to the community. Development includes a Techniques and Resources section for the publication of new methods, datasets, and other types of resources. Papers describing new techniques should include a proof-of-principle demonstration that the technique is valuable to the developmental biology community; they need not include in-depth follow-up analysis. The technique must be described in sufficient detail to be easily replicated by other investigators. Development will also consider protocol-type papers of exceptional interest to the community. We welcome submission of Resource papers, for example those reporting new databases, systems-level datasets, or genetic resources of major value to the developmental biology community. For all papers, the data or resource described must be made available to the community with minimal restrictions upon publication. To aid navigability, Development has dedicated sections of the journal to stem cells & regeneration and to human development. The criteria for acceptance into these sections is identical to those outlined above. Authors and editors are encouraged to nominate appropriate manuscripts for inclusion in one of these sections.